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Tdark
TMEM139
Transmembrane protein 139

Protein Summary
Description
May be involved in cellular trafficking of proteins such as SLC4A1.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359333
  • ENSP00000352284
  • ENSG00000178826
  • ENST00000409102
  • ENSP00000386879
  • ENST00000409244
  • ENSP00000386335
  • ENST00000409541
  • ENSP00000387044
  • ENST00000410004
  • ENSP00000386564
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.8
tissue
0.58
tissue sample
0.51
microRNA
0.5
phenotype
0.38


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.87   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.87   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (6)
RPS6KA3
Tchem
Family:  Kinase
Novelty:  0.00221219
p_int:  0.992712911
p_ni:  0.00728708
p_wrong:  9e-9
Score:  0.455
Data Source:  BioPlex,STRINGDB
TRIM68
Tbio
Family:  Enzyme
Novelty:  0.11729189
p_int:  0.976136688
p_ni:  0.023863312
Score:  0.228
Data Source:  BioPlex,STRINGDB
OSGEP
Tbio
Family:  Enzyme
Novelty:  0.0106198
Score:  0.619
Data Source:  STRINGDB
ZNF532
Tdark
Family:  TF
Novelty:  0.32269483
Score:  0.457
Data Source:  STRINGDB
ZNF398
Tbio
Family:  TF
Novelty:  0.01578856
Score:  0.426
Data Source:  STRINGDB
FIGN
Tbio
Family:  Enzyme
Novelty:  0.02804869
Score:  0.414
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
3
1
3
85.2
basophil percentage of leukocytes
1
1
1
84.9
monocyte count
1
1
1
74.8
monocyte percentage of leukocytes
1
1
1
46.1
serum gamma-glutamyl transferase measurement
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
3
85.2
basophil percentage of leukocytes
1
84.9
monocyte count
1
74.8
monocyte percentage of leukocytes
1
46.1
serum gamma-glutamyl transferase measurement
1
44.2
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 139
VGNC:4538
463803
Mouse
MGI:1924444
109218
Rat
RGD:1594187
680244
Dog
transmembrane protein 139
VGNC:47475
608825
Horse
transmembrane protein 139
VGNC:24200
100056093
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 139
Mouse
Rat
Dog
transmembrane protein 139
Horse
transmembrane protein 139
Publication Statistics
PubMed Score 0.87
PubMed score by year
PubTator Score 0.50
PubTator score by year
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Related Publications
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PMID
Year
Title