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Tdark
TMEM132E
Transmembrane protein 132E

Protein Summary
Description
Required for normal inner ear hair cell function and hearing.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321639
  • ENSP00000316532
  • ENSG00000181291

Symbol
  • DFNB99
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.72
transcription factor
0.59
PubMedID
0.58
histone modification site profile
0.56
cell line
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.55   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 61   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.55   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 61   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (36)
TMEM212
Tdark
Novelty:  0.94290731
Score:  0.659
Data Source:  STRINGDB
TMEM211
Tdark
Novelty:  6.51386952
Score:  0.65
Data Source:  STRINGDB
GPR137C
Tdark
Novelty:  3.30248948
Score:  0.629
Data Source:  STRINGDB
TMEM221
Tdark
Novelty:  6.39119451
Score:  0.617
Data Source:  STRINGDB
NXPE2
Tdark
Novelty:  1.32460466
Score:  0.588
Data Source:  STRINGDB
TMEM150C
Tdark
Novelty:  0.11603552
Score:  0.582
Data Source:  STRINGDB
ADGRB2
Tbio
Family:  GPCR
Novelty:  0.06085196
Score:  0.577
Data Source:  STRINGDB
INSYN2
Tdark
Novelty:  2.55244594
Score:  0.574
Data Source:  STRINGDB
FRMPD3
Tdark
Novelty:  4.19248406
Score:  0.574
Data Source:  STRINGDB
OVOL3
Tdark
Family:  TF
Novelty:  0.77470886
Score:  0.566
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
macrophage inflammatory protein 1b measurement
1
2
2
51.3
insomnia measurement
1
1
0
1.2
1.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
macrophage inflammatory protein 1b measurement
2
51.3
insomnia measurement
0
1.2
1.1
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 132E
VGNC:9724
468210
Macaque
transmembrane protein 132E
715004
Mouse
MGI:2685490
270893
Rat
RGD:1565522
287564
Dog
transmembrane protein 132E
VGNC:47471
491147
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 132E
Macaque
transmembrane protein 132E
Mouse
Rat
Dog
transmembrane protein 132E
Publication Statistics
PubMed Score 4.55
PubMed score by year
PubTator Score 2.33
PubTator score by year
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Related Publications
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PMID
Year
Title