TMEM132A
Transmembrane protein 132A
Protein Summary
May play a role in embryonic and postnatal development of the brain. Increased resistance to cell death induced by serum starvation in cultured cells. Regulates cAMP-induced GFAP gene expression via STAT3 phosphorylation (By similarity). This gene encodes a protein that is highly similar to the rat Grp78-binding protein (GBP). Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
- ENST00000005286
- ENSP00000005286
- ENSG00000006118
- ENST00000453848
- ENSP00000405823
- HSPA5BP1
- KIAA1583
- GBP
- HSPA5BP1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.85 | ||
cellular component | 0.77 | ||
tissue sample | 0.63 | ||
disease perturbation | 0.56 | ||
cell line | 0.55 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4.16 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 64 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4.16 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 64 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (166)
LYPD2
Novelty: 0.55307434
p_int: 0.999839766
p_ni: 0.000160233
p_wrong: 1e-9
Data Source: BioPlex
DEFA1
Novelty: 0.01027492
p_int: 0.984256357
p_ni: 0.015743643
Score: 0.208
Data Source: BioPlex,STRINGDB
MGAT4C
Family: Enzyme
Novelty: 0.19680806
p_int: 0.981020247
p_ni: 0.018979753
Data Source: BioPlex
PCDHGC5
Novelty: 0.39651826
p_int: 0.938555735
p_ni: 0.061441321
p_wrong: 0.000002944
Data Source: BioPlex
PCDHGA7
Novelty: 1.67766171
p_int: 0.938513017
p_ni: 0.060990458
p_wrong: 0.000496525
Data Source: BioPlex
DNASE2B
Family: Enzyme
Novelty: 0.02506932
p_int: 0.93707525
p_ni: 0.06292475
Data Source: BioPlex
Nearest Tclin Targets
Pathways (4)
Reactome (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism of proteins | ||||
Reactome | Post-translational protein modification | ||||
Reactome | Post-translational protein phosphorylation | ||||
Reactome | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism of proteins | ||||
Post-translational protein modification | ||||
Post-translational protein phosphorylation | ||||
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | ||||
Viral Interactions (0)
Gene Ontology Terms (9)
Components (7)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-SubCell | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-SubCell | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
4 | 3 | 0 | 1.2 | 90.4 | |||||
cathepsin L1 measurement | 1 | 1 | 1 | 77.3 | |||||
CD6 measurement | 1 | 1 | 1 | 67.3 | |||||
2 | 1 | 0 | 1.1 | 61.4 | |||||
1 | 1 | 0 | 1.1 | 47.7 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.2 | 90.4 | |||||
cathepsin L1 measurement | 1 | 77.3 | |||||
CD6 measurement | 1 | 67.3 | |||||
0 | 1.1 | 61.4 | |||||
0 | 1.1 | 47.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | transmembrane protein 132A | VGNC:980 | 466624 | |||||
Mouse | MGI:2147810 | 98170 | ||||||
Rat | RGD:727936 | 338474 | ||||||
Dog | transmembrane protein 132A | VGNC:47467 | 612353 | |||||
Horse | transmembrane protein 132A [Source:HGNC Symbol;Acc:HGNC:31092] | |||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | transmembrane protein 132A | |||||
Mouse | ||||||
Rat | ||||||
Dog | transmembrane protein 132A | |||||
Horse | transmembrane protein 132A [Source:HGNC Symbol;Acc:HGNC:31092] | |||||
Publication Statistics
PubMed Score 4.16
PubMed score by year
PubTator Score 217.07
PubTator score by year
Related Publications
Text Mined References (9)
GeneRif Annotations (2)
Items per page:
0 of 0
PMID | Year | Title |
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