Tbio TMEM132A Transmembrane protein 132A

Protein Summary

Description

May play a role in embryonic and postnatal development of the brain. Increased resistance to cell death induced by serum starvation in cultured cells. Regulates cAMP-induced GFAP gene expression via STAT3 phosphorylation (By similarity). This gene encodes a protein that is highly similar to the rat Grp78-binding protein (GBP). Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q24JP5
• Q69YU7
• Q86VZ8
• Q86W97
• Q9H8K3
• Q9HCI9
• Q9NWY0

Gene Name

• TMEM132A

Ensembl ID

• ENST00000005286
• ENSP00000005286
• ENSG00000006118
• ENST00000453848
• ENSP00000405823

Symbol

• HSPA5BP1
• KIAA1583
• GBP
• HSPA5BP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.85
cellular component	0.77
tissue sample	0.63
disease perturbation	0.56
cell line	0.55

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.11   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 64   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.11   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0