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Tdark
TMEM132A
Transmembrane protein 132A

Protein Summary
Description
May play a role in embryonic and postnatal development of the brain. Increased resistance to cell death induced by serum starvation in cultured cells. Regulates cAMP-induced GFAP gene expression via STAT3 phosphorylation (By similarity). This gene encodes a protein that is highly similar to the rat Grp78-binding protein (GBP). Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000005286
  • ENSP00000005286
  • ENSG00000006118
  • ENST00000453848
  • ENSP00000405823

Symbol
  • HSPA5BP1
  • KIAA1583
  • GBP
  • HSPA5BP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.85
cellular component
0.77
tissue sample
0.63
disease perturbation
0.56
cell line
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.16   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 64   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.16   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (166)
LYPD2
Tdark
Novelty:  0.55307434
p_int:  0.999839766
p_ni:  0.000160233
p_wrong:  1e-9
Data Source:  BioPlex
DEFA5
Tbio
Novelty:  0.00863727
p_int:  0.999182375
p_ni:  0.000817625
Data Source:  BioPlex
PTCH1
Tbio
Novelty:  0.00077635
p_int:  0.997844209
p_ni:  0.002155791
Data Source:  BioPlex
GAA
Tclin
Family:  Enzyme
Novelty:  0.0063246
p_int:  0.99143224
p_ni:  0.00856776
Data Source:  BioPlex
DEFA1
Tbio
Novelty:  0.01027492
p_int:  0.984256357
p_ni:  0.015743643
Score:  0.208
Data Source:  BioPlex,STRINGDB
MGAT4C
Tdark
Family:  Enzyme
Novelty:  0.19680806
p_int:  0.981020247
p_ni:  0.018979753
Data Source:  BioPlex
TMEM25
Tdark
Novelty:  0.35505784
p_int:  0.949951698
p_ni:  0.050048302
Data Source:  BioPlex
PCDHGC5
Tdark
Novelty:  0.39651826
p_int:  0.938555735
p_ni:  0.061441321
p_wrong:  0.000002944
Data Source:  BioPlex
PCDHGA7
Tdark
Novelty:  1.67766171
p_int:  0.938513017
p_ni:  0.060990458
p_wrong:  0.000496525
Data Source:  BioPlex
DNASE2B
Tbio
Family:  Enzyme
Novelty:  0.02506932
p_int:  0.93707525
p_ni:  0.06292475
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Post-translational protein phosphorylation
Reactome
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
Post-translational protein phosphorylation
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
3
0
1.2
90.4
cathepsin L1 measurement
1
1
1
77.3
CD6 measurement
1
1
1
67.3
2
1
0
1.1
61.4
1
1
0
1.1
47.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
90.4
cathepsin L1 measurement
1
77.3
CD6 measurement
1
67.3
0
1.1
61.4
0
1.1
47.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 132A
VGNC:980
466624
Mouse
MGI:2147810
98170
Rat
RGD:727936
338474
Dog
transmembrane protein 132A
VGNC:47467
612353
Horse
transmembrane protein 132A [Source:HGNC Symbol;Acc:HGNC:31092]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 132A
Mouse
Rat
Dog
transmembrane protein 132A
Horse
transmembrane protein 132A [Source:HGNC Symbol;Acc:HGNC:31092]
Publication Statistics
PubMed Score 4.16
PubMed score by year
PubTator Score 217.07
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title