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Tdark
TMEM131
Transmembrane protein 131

Protein Summary
Description
May play a role in the immune response to viral infection.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000186436
  • ENSP00000186436
  • ENSG00000075568

Symbol
  • KIAA0257
  • RW1
  • RW1
  • CC28
  • YR-23
  • PRO1048
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
transcription factor binding site profile
0.91
tissue sample
0.66
histone modification site profile
0.64
kinase perturbation
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.02   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 20   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.02   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 20   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (37)
CSTL1
Tbio
Novelty:  0.13370814
p_int:  0.996026103
p_ni:  0.003973897
Data Source:  BioPlex
GABRA3
Tclin
Family:  IC
Novelty:  0.02180091
p_int:  0.99352543
p_ni:  0.00647457
Data Source:  BioPlex
GRAMD1B
Tbio
Novelty:  0.2994102
p_int:  0.987717763
p_ni:  0.012282237
Data Source:  BioPlex
RXFP1
Tchem
Family:  GPCR
Novelty:  0.00580827
p_int:  0.981496381
p_ni:  0.018503619
Data Source:  BioPlex
OS9
Tbio
Novelty:  0.01490339
p_int:  0.978765401
p_ni:  0.021234591
p_wrong:  9e-9
Data Source:  BioPlex
TNFSF13B
Tclin
Novelty:  0.00069885
p_int:  0.969565629
p_ni:  0.030434354
p_wrong:  1.7e-8
Data Source:  BioPlex
LYZL1
Tbio
Family:  Enzyme
Novelty:  0.10945096
p_int:  0.961361748
p_ni:  0.03863825
p_wrong:  2e-9
Data Source:  BioPlex
TMEM106A
Tbio
Novelty:  0.32470607
p_int:  0.955034065
p_ni:  0.044965935
Data Source:  BioPlex
LRRTM1
Tbio
Novelty:  0.0409182
p_int:  0.941577308
p_ni:  0.058422692
Data Source:  BioPlex
DEFA1
Tbio
Novelty:  0.01027492
p_int:  0.931647274
p_ni:  0.068352725
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
3
1
3
75.6
mathematical ability
4
1
4
73.8
cortical thickness
1
1
1
61.5
educational attainment
1
2
2
58.1
smoking status measurement
2
1
2
57.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
3
75.6
mathematical ability
4
73.8
cortical thickness
1
61.5
educational attainment
2
58.1
smoking status measurement
2
57.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 131
VGNC:480
459428
Macaque
transmembrane protein 131
711688
Mouse
MGI:1927110
56030
Rat
RGD:1309266
316335
Dog
transmembrane protein 131
VGNC:47465
474566
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 131
Macaque
transmembrane protein 131
Mouse
Rat
Dog
transmembrane protein 131
Publication Statistics
PubMed Score 75.02
PubMed score by year
PubTator Score 35.83
PubTator score by year
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Related Publications
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PMID
Year
Title