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Tdark
TMEM130
Transmembrane protein 130

IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.83   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 24   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.83   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 24   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (89)
TRIM13
Tbio
Family:  Enzyme
Novelty:  0.00085649
p_int:  0.999993403
p_ni:  0.000006462
p_wrong:  1.34e-7
Data Source:  BioPlex
ATP7A
Tbio
Family:  Enzyme
Novelty:  0.00064155
p_int:  0.999030504
p_ni:  0.000969479
p_wrong:  1.7e-8
Data Source:  BioPlex
FGFR2
Tclin
Family:  Kinase
Novelty:  0.00066613
p_int:  0.99496581
p_ni:  0.004429606
p_wrong:  0.000604584
Data Source:  BioPlex
FAM20B
Tdark
Family:  Enzyme
Novelty:  0.07347685
p_int:  0.993139349
p_ni:  0.006806759
p_wrong:  0.000053892
Data Source:  BioPlex
XPO5
Tbio
Novelty:  0.0040002
p_int:  0.987813731
p_ni:  0.012186269
Data Source:  BioPlex
GIP
Tbio
Novelty:  0.0007219
p_int:  0.987623937
p_ni:  4e-9
p_wrong:  0.01237606
Data Source:  BioPlex
INTS1
Tbio
Novelty:  0.17523407
p_int:  0.986496958
p_ni:  0.013503042
Data Source:  BioPlex
TYK2
Tclin
Family:  Kinase
Novelty:  0.00237955
p_int:  0.982291547
p_ni:  0.017708453
Data Source:  BioPlex
LSR
Tbio
Novelty:  0.00528058
p_int:  0.971504415
p_ni:  0.028495585
Data Source:  BioPlex
RHOBTB3
Tbio
Novelty:  0.09149494
p_int:  0.959323745
p_ni:  0.040523165
p_wrong:  0.00015309
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
2
2
82.4
mean corpuscular volume
1
1
1
67.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
2
82.4
mean corpuscular volume
1
67.9
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:3607706
243339
Rat
RGD:1563248
304280
Dog
transmembrane protein 130
VGNC:47464
608852
Horse
transmembrane protein 130
VGNC:24193
100063055
Cow
transmembrane protein 130
VGNC:35963
504372
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
transmembrane protein 130
Horse
transmembrane protein 130
Cow
transmembrane protein 130
Publication Statistics
PubMed Score 1.83
PubMed score by year
PubTator Score 0.20
PubTator score by year
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Related Publications
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PMID
Year
Title