Tdark TMEM128 Transmembrane protein 128

Protein Summary

Uniprot Accession IDs

• Q5BJH2
• B4DHS7
• D3DVS1
• D3DVS3
• Q5H9U6
• Q96I94

Gene Name

• TMEM128

Ensembl ID

• ENST00000254742
• ENSP00000254742
• ENSG00000132406
• ENST00000382753
• ENSP00000372201

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.94
histone modification site profile	0.93
cell type or tissue	0.66
tissue sample	0.66
tissue	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.16   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 9   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.16   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 9   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

tutorial

No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (41)

Explore Interacting Targets

1 – 10 of 41

• See Interactions on String-DB

RTN4

Tbio

Novelty:  0.00080371

p_int:  0.999997691

p_ni:  0.000002309

Score:  0.641

Data Source:  BioPlex,STRINGDB

REEP6

Tbio

Novelty:  0.10645981

p_int:  0.999952679

p_ni:  0.000047321

Score:  0.195

Data Source:  BioPlex,STRINGDB

SLC44A1

Tbio

Family:  Transporter

Novelty:  0.01499456

p_int:  0.99995118

p_ni:  0.000036385

p_wrong:  0.000012435

Score:  0.165

Data Source:  BioPlex,STRINGDB

CD226

Tbio

Novelty:  0.00374102

p_int:  0.999651191

p_ni:  2.22e-7

p_wrong:  0.000348587

Data Source:  BioPlex

RTN2

Tbio

Novelty:  0.05184418

p_int:  0.9996495

p_ni:  0.000350493

p_wrong:  7e-9

Score:  0.195

Data Source:  BioPlex,STRINGDB

REEP5

Tbio

Novelty:  0.00160455

p_int:  0.998974482

p_ni:  0.001025462

p_wrong:  5.6e-8

Score:  0.356

Data Source:  BioPlex,STRINGDB

FUNDC2

Tbio

Novelty:  0.09695817

p_int:  0.997680417

p_ni:  0.00174486

p_wrong:  0.000574723

Score:  0.165

Data Source:  BioPlex,STRINGDB

PLSCR1

Tbio

Family:  Enzyme

Novelty:  0.01483138

p_int:  0.997070701

p_ni:  0.002814752

p_wrong:  0.000114547

Score:  0.542

Data Source:  BioPlex,STRINGDB

BCS1L

Tbio

Family:  Enzyme

Novelty:  0.01764582

p_int:  0.99414319

p_ni:  0.005856786

p_wrong:  2.3e-8

Data Source:  BioPlex

TMEM208

Tdark

Novelty:  0.63059333

p_int:  0.993029646

p_ni:  0.000130039

p_wrong:  0.006840315

Score:  0.719

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (1)

Components (1)

Find Similar Targets

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
integral component of membrane	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (1)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
serum metabolite measurement	EFO_0005653	1	1	1		6.5

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 1 of 1

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
serum metabolite measurement	EFO_0005653	1		6.5

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix

GWAS Trait Find Similar Targets

No Header	No Header
serum metabolite measurement

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	transmembrane protein 128	VGNC:726	461088
Macaque	transmembrane protein 128 [Source:HGNC Symbol;Acc:HGNC:28201]
Mouse	transmembrane protein 128	MGI:1913559	66309
Rat	transmembrane protein 128	RGD:1310481	360952
Dog	transmembrane protein 128	VGNC:47462	479094

Species	Name	OMA	EggNOG	Inparanoid
Chimp	transmembrane protein 128
Macaque	transmembrane protein 128 [Source:HGNC Symbol;Acc:HGNC:28201]
Mouse	transmembrane protein 128
Rat	transmembrane protein 128
Dog	transmembrane protein 128

Publication Statistics

PubMed Score 0.16

PubMed score by year

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Related Publications

Text Mined References (7)

Items per page:

10

0 of 0

PMID	Year	Title