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Tbio
TMEM119
Transmembrane protein 119

Protein Summary
Description
Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts (PubMed:20025746). May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway. Upregulates the expression of ATF4, a transcription factor which plays a central role in osteoblast differentiation. Essential for normal spermatogenesis and late testicular differentiation (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000392806
  • ENSP00000376553
  • ENSG00000183160

Symbol
  • OBIF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.59
gene perturbation
0.51
cellular component
0.46
small molecule perturbation
0.46
microRNA
0.43


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.97   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 12   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.97   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 12   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (25)
P2RY12
Tclin
Family:  GPCR
Novelty:  0.00035406
Score:  0.729
Data Source:  STRINGDB
GPR34
Tchem
Family:  GPCR
Novelty:  0.03810628
Score:  0.71
Data Source:  STRINGDB
OLFML3
Tbio
Novelty:  0.09742366
Score:  0.71
Data Source:  STRINGDB
CX3CR1
Tchem
Family:  GPCR
Novelty:  0.00114874
Score:  0.605
Data Source:  STRINGDB
TREM2
Tbio
Novelty:  0.00228007
Score:  0.582
Data Source:  STRINGDB
AIF1
Tbio
Novelty:  0.00049167
Score:  0.571
Data Source:  STRINGDB
P2RY13
Tchem
Family:  GPCR
Novelty:  0.01511227
Score:  0.55
Data Source:  STRINGDB
RUNX2
Tbio
Family:  TF
Novelty:  0.00028804
Score:  0.542
Data Source:  STRINGDB
FCRL2
Tbio
Novelty:  0.08807798
Score:  0.509
Data Source:  STRINGDB
SOWAHD
Tdark
Novelty:  6.91525424
Score:  0.505
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
4
4
4
64.2
heel bone mineral density
2
1
2
44.2
reticulocyte count
2
1
2
11.9
reticulocyte measurement
1
1
1
8.2
optic disc size measurement
1
1
1
7.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
4
64.2
heel bone mineral density
2
44.2
reticulocyte count
2
11.9
reticulocyte measurement
1
8.2
optic disc size measurement
1
7.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
transmembrane protein 119
705921
Mouse
MGI:2385228
231633
Rat
RGD:1307573
304581
Dog
transmembrane protein 119
VGNC:47455
611689
Horse
transmembrane protein 119
VGNC:24185
100066847
Species
Name
OMA
EggNOG
Inparanoid
Macaque
transmembrane protein 119
Mouse
Rat
Dog
transmembrane protein 119
Horse
transmembrane protein 119
Publication Statistics
PubMed Score 47.97
PubMed score by year
PubTator Score 6.18
PubTator score by year
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Related Publications
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PMID
Year
Title