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Tdark
TMEM114
Transmembrane protein 114

Protein Summary
Description
This gene encodes a glycosylated transmembrane protein that plays a role in lens and eye development. Mutations in this gene, including a t(16;22)(p13.3;q11.2) translocation, are associated with congenital and juvenile cataract disorders. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000620492
  • ENSP00000484263
  • ENSG00000232258
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.65
transcription factor binding site profile
0.46
chemical
0.41
cellular component
0.38
gene perturbation
0.37


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.98   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 12   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.98   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 12   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (43)
RCHY1
Tbio
Novelty:  0.01853663
Score:  0.8
Data Source:  STRINGDB
CHMP4B
Tbio
Novelty:  0.01391352
Score:  0.777
Data Source:  STRINGDB
LIM2
Tbio
Novelty:  0.01252353
Score:  0.763
Data Source:  STRINGDB
CRYBB2
Tbio
Novelty:  0.00721869
Score:  0.744
Data Source:  STRINGDB
CRYBB1
Tbio
Novelty:  0.01083645
Score:  0.74
Data Source:  STRINGDB
GJA3
Tbio
Novelty:  0.00638283
Score:  0.737
Data Source:  STRINGDB
BFSP1
Tbio
Novelty:  0.01519136
Score:  0.734
Data Source:  STRINGDB
CRYBB3
Tbio
Novelty:  0.0455879
Score:  0.708
Data Source:  STRINGDB
CRYBA4
Tbio
Novelty:  0.03692663
Score:  0.703
Data Source:  STRINGDB
CRYGD
Tbio
Novelty:  0.00246109
Score:  0.699
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
autoimmune thyroid disease
1
1
0
1.1
7.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
autoimmune thyroid disease
0
1.1
7.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
transmembrane protein 114
708628
Mouse
MGI:1921970
74720
Rat
RGD:1560593
501675
Dog
transmembrane protein 114
VGNC:54079
490014
Cow
transmembrane protein 114
VGNC:35951
787012
Species
Name
OMA
EggNOG
Inparanoid
Macaque
transmembrane protein 114
Mouse
Rat
Dog
transmembrane protein 114
Cow
transmembrane protein 114
Publication Statistics
PubMed Score 3.98
PubMed score by year
PubTator Score 4.20
PubTator score by year
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Related Publications
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PMID
Year
Title