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Tdark
TMEM106C
Transmembrane protein 106C

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256686
  • ENSP00000256686
  • ENSG00000134291
  • ENST00000429772
  • ENSP00000400471
  • ENST00000449758
  • ENSP00000402705
  • ENST00000550552
  • ENSP00000449737
  • ENST00000552561
  • ENSP00000446657

Symbol
  • EMOC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
kinase perturbation
0.84
virus perturbation
0.76
histone modification site profile
0.73
tissue
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.09   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 31   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.09   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 31   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (18)
MPG
Tchem
Family:  Enzyme
Novelty:  0.00373538
Score:  0.788
Data Source:  STRINGDB
TMEM117
Tbio
Novelty:  0.38616851
Score:  0.706
Data Source:  STRINGDB
OXT
Tbio
Novelty:  0.00005116
Score:  0.669
Data Source:  STRINGDB
C12orf4
Tdark
Novelty:  0.35695485
Score:  0.619
Data Source:  STRINGDB
ITFG2
Tbio
Novelty:  0.41720651
Score:  0.599
Data Source:  STRINGDB
TMCO3
Tdark
Novelty:  1.16719823
Score:  0.583
Data Source:  STRINGDB
VPS13D
Tdark
Novelty:  0.12578583
Score:  0.549
Data Source:  STRINGDB
MARCH4
Tbio
Family:  Enzyme
Novelty:  0.20869934
Score:  0.539
Data Source:  STRINGDB
ZBTB22
Tbio
Novelty:  0.00365381
Score:  0.53
Data Source:  STRINGDB
PRICKLE1
Tbio
Novelty:  0.03175916
Score:  0.52
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
2
6
6
96.4
blood protein measurement
1
2
2
78.9
inflammatory biomarker measurement
1
1
0
47.6
63.4
platelet crit
2
2
2
57.9
appendicular lean mass
2
2
2
46.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
6
96.4
blood protein measurement
2
78.9
inflammatory biomarker measurement
0
47.6
63.4
platelet crit
2
57.9
appendicular lean mass
2
46.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 106C
VGNC:5627
451859
Macaque
transmembrane protein 106C
704741
Mouse
MGI:1196384
380967
Rat
RGD:1311532
315286
Dog
transmembrane protein 106C
VGNC:47447
477630
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 106C
Macaque
transmembrane protein 106C
Mouse
Rat
Dog
transmembrane protein 106C
Publication Statistics
PubMed Score 6.09
PubMed score by year
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Related Publications
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0 of 0
PMID
Year
Title