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Tdark
TMEM105
Transmembrane protein 105

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332900
  • ENSP00000329795
  • ENSG00000185332
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.47
tissue
0.43
disease
0.4
transcription factor binding site profile
0.38
tissue sample
0.37


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.29   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 12   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.29   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 12   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (12)
SLC38A10
Tdark
Family:  Transporter
Novelty:  0.47522526
Score:  0.683
Data Source:  STRINGDB
SCNN1D
Tbio
Family:  IC
Novelty:  0.06191685
Score:  0.559
Data Source:  STRINGDB
ACAP3
Tbio
Novelty:  0.19558023
Score:  0.557
Data Source:  STRINGDB
DIP2B
Tdark
Novelty:  0.14642544
Score:  0.552
Data Source:  STRINGDB
ZNF385A
Tbio
Novelty:  0.46605402
Score:  0.541
Data Source:  STRINGDB
DNAAF5
Tbio
Novelty:  0.27921814
Score:  0.529
Data Source:  STRINGDB
MRGPRG
Tdark
Family:  GPCR
Novelty:  0.13744852
Score:  0.48
Data Source:  STRINGDB
POTED
Tbio
Novelty:  0.03732981
Score:  0.477
Data Source:  STRINGDB
ALKAL2
Tbio
Novelty:  0.12969286
Score:  0.45
Data Source:  STRINGDB
ARIH2
Tbio
Family:  Enzyme
Novelty:  0.03455224
Score:  0.444
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
5
5
73
heel bone mineral density
2
1
2
71.3
lifestyle measurement
1
1
1
49.5
hematocrit
1
1
1
40.7
vitamin D measurement
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
5
73
heel bone mineral density
2
71.3
lifestyle measurement
1
49.5
hematocrit
1
40.7
vitamin D measurement
1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 105
VGNC:14201
743888
Macaque
transmembrane protein 105 [Source:HGNC Symbol;Acc:HGNC:26794]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 105
Macaque
transmembrane protein 105 [Source:HGNC Symbol;Acc:HGNC:26794]
Publication Statistics
PubMed Score 0.29
PubMed score by year
PubTator Score 0.25
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title