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Tdark
TMEM104
Transmembrane protein 104

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335464
  • ENSP00000334849
  • ENSG00000109066
  • ENST00000582330
  • ENSP00000461922
  • ENST00000582773
  • ENSP00000463205
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.85
cell type or tissue
0.66
tissue sample
0.66
small molecule perturbation
0.64
cell line
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 27   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 27   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (4)
SLC22A16
Tbio
Family:  Transporter
Novelty:  0.03379851
p_int:  0.999740594
p_ni:  0.000245459
p_wrong:  0.000013947
Score:  0.243
Data Source:  BioPlex,STRINGDB
LRRC55
Tbio
Family:  IC
Novelty:  0.25121277
p_int:  0.999439545
p_ni:  0.000356259
p_wrong:  0.000204196
Data Source:  BioPlex
HTR3C
Tchem
Family:  IC
Novelty:  0.112097
p_int:  0.99577699
p_ni:  0.003374161
p_wrong:  0.000848849
Score:  0.188
Data Source:  BioPlex,STRINGDB
FADS6
Tdark
Family:  Enzyme
Novelty:  1.07260726
Score:  0.524
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
6
4
7
97.5
monocyte count
3
4
4
88.6
lymphocyte count
5
5
6
85.2
leukocyte count
4
6
8
83.3
myeloid white cell count
2
2
2
82.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
7
97.5
monocyte count
4
88.6
lymphocyte count
6
85.2
leukocyte count
8
83.3
myeloid white cell count
2
82.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 104
VGNC:14200
468325
Macaque
transmembrane protein 104
698592
Mouse
MGI:2444222
320534
Rat
RGD:1307953
303670
Dog
transmembrane protein 104
VGNC:47445
100856760
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 104
Macaque
transmembrane protein 104
Mouse
Rat
Dog
transmembrane protein 104
Publication Statistics
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PMID
Year
Title