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Tbio
TMEFF1
Tomoregulin-1

Protein Summary
Description
May inhibit NODAL and BMP signaling during neural patterning (By similarity). May be a tumor suppressor in brain cancers. This locus represents naturally occurring read-through transcription from the neighboring MSANTD3 (Myb/SANT-like DNA-binding domain containing 3) and TMEFF1 (transmembrane protein with EGF-like and two follistatin-like domains 1) genes. The read-through transcript encodes a fusion protein that shares sequence identity with the products of each individual gene. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374879
  • ENSP00000364013
  • ENSG00000241697

Symbol
  • C9orf2
  • TR-1
  • H7365
  • C9orf2
  • TMEFF1
  • C9orf3-TMEFF1
  • C9orf30-TMEFF1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.85
transcription factor binding site profile
0.62
gene perturbation
0.61
transcription factor perturbation
0.61
small molecule perturbation
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.12   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 199   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.12   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 199   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (20)
GPR183
Tchem
Family:  GPCR
Novelty:  0.02005679
p_int:  0.999992146
p_ni:  1.22e-7
p_wrong:  0.000007732
Data Source:  BioPlex
STEAP3
Tbio
Family:  Enzyme
Novelty:  0.02042104
p_int:  0.99997922
p_ni:  0.00002078
Data Source:  BioPlex
ZDHHC5
Tbio
Family:  Enzyme
Novelty:  0.05205767
p_int:  0.99997695
p_ni:  0.000023047
p_wrong:  3e-9
Score:  0.692
Data Source:  BioPlex,STRINGDB
CLDND1
Tbio
Novelty:  0.06681793
p_int:  0.999636509
p_ni:  0.000080331
p_wrong:  0.000283161
Score:  0.546
Data Source:  BioPlex,STRINGDB
DHRS2
Tbio
Family:  Enzyme
Novelty:  0.002032
p_int:  0.999575605
p_ni:  0.000029682
p_wrong:  0.000394713
Score:  0.188
Data Source:  BioPlex,STRINGDB
FGF2
Tchem
Novelty:  0.00007856
p_int:  0.9994368
p_ni:  6.34e-7
p_wrong:  0.000562566
Score:  0.351
Data Source:  BioPlex,STRINGDB
BCS1L
Tbio
Family:  Enzyme
Novelty:  0.01764582
p_int:  0.999215119
p_ni:  0.000784879
p_wrong:  2e-9
Score:  0.213
Data Source:  BioPlex,STRINGDB
HADHA
Tbio
Novelty:  0.00385746
p_int:  0.997565506
p_ni:  1.7e-8
p_wrong:  0.002434477
Data Source:  BioPlex
THNSL1
Tdark
Family:  Enzyme
Novelty:  1.98275016
p_int:  0.996604926
p_ni:  0.003394902
p_wrong:  1.72e-7
Score:  0.179
Data Source:  BioPlex,STRINGDB
INTS7
Tdark
Novelty:  0.04592325
p_int:  0.996027509
p_ni:  0.00397249
p_wrong:  1e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
1
1
0
6.9
42.6
glomerular filtration rate
1
1
1
19.6
BMI-adjusted waist-hip ratio
1
1
1
0.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
0
6.9
42.6
glomerular filtration rate
1
19.6
BMI-adjusted waist-hip ratio
1
0.4
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein with EGF like and two follistatin like domains 1
VGNC:8943
464619
Mouse
MGI:1926810
230157
Rat
RGD:62005
63845
Opossum
transmembrane protein with EGF like and two follistatin like domains 1
100020714
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein with EGF like and two follistatin like domains 1
Mouse
Rat
Opossum
transmembrane protein with EGF like and two follistatin like domains 1
Publication Statistics
PubMed Score 14.12
PubMed score by year
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Related Publications
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PMID
Year
Title