You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TMED9
Transmembrane emp24 domain-containing protein 9

Protein Summary
Description
Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer-dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 isoform PTPB. This gene is a member of a family of genes encoding transport proteins located in the endoplasmic reticulum and the Golgi. A similar gene in mouse is the target of microRNA miR-296, which is part of an imprinted cluster. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332598
  • ENSP00000330945
  • ENSG00000184840

Symbol
  • GP25L2
  • p25
  • GMP25
  • p24a2
  • HSGP25L2G
  • p24alpha2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
transcription factor perturbation
0.88
interacting protein
0.87
cellular component
0.86
transcription factor binding site profile
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.66   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.66   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (189)
TMED7
Tdark
Novelty:  0.31193294
p_int:  0.999826387
p_ni:  0.000173613
Score:  0.96
Data Source:  BioPlex,STRINGDB
LIPG
Tchem
Family:  Enzyme
Novelty:  0.00412129
p_int:  0.999546962
p_ni:  0.000453038
Score:  0.189
Data Source:  BioPlex,STRINGDB
SPPL2B
Tchem
Family:  Enzyme
Novelty:  0.0274774
p_int:  0.966888295
p_ni:  0.033111704
Score:  0.165
Data Source:  BioPlex,STRINGDB
FGF3
Tbio
Novelty:  0.00474087
p_int:  0.951958551
p_ni:  0.048041448
p_wrong:  1e-9
Data Source:  BioPlex
CHST8
Tbio
Family:  Enzyme
Novelty:  0.03489772
p_int:  0.920234932
p_ni:  0.079765068
Score:  0.209
Data Source:  BioPlex,STRINGDB
CDK5RAP3
Tbio
Novelty:  0.03628071
p_int:  0.887300733
p_ni:  0.112699267
Score:  0.194
Data Source:  BioPlex,STRINGDB
TMED2
Tbio
Novelty:  0.03731104
Score:  0.999
Data Source:  Reactome,STRINGDB
TMED10
Tbio
Novelty:  0.02742083
Score:  0.999
Data Source:  Reactome,STRINGDB
NAGLU
Tbio
Family:  Enzyme
Novelty:  0.01033079
Score:  0.976
Data Source:  STRINGDB
SEC22B
Tbio
Novelty:  0.03035448
Score:  0.952
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
COPI-mediated anterograde transport
Reactome
ER to Golgi Anterograde Transport
Reactome
Golgi-to-ER retrograde transport
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPI-dependent Golgi-to-ER retrograde traffic
COPI-mediated anterograde transport
ER to Golgi Anterograde Transport
Golgi-to-ER retrograde transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
49.5
heel bone mineral density
1
1
1
40.7
mathematical ability
1
1
1
6.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
49.5
heel bone mineral density
1
40.7
mathematical ability
1
6.5
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane p24 trafficking protein 9
VGNC:7160
462315
Mouse
MGI:1914761
67511
Rat
RGD:1307627
361207
Horse
transmembrane p24 trafficking protein 9
VGNC:24172
100068443
Cow
transmembrane emp24 protein transport domain containing 9
618580
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane p24 trafficking protein 9
Mouse
Rat
Horse
transmembrane p24 trafficking protein 9
Cow
transmembrane emp24 protein transport domain containing 9
Publication Statistics
PubMed Score 7.66
PubMed score by year
PubTator Score 11.39
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title