Tbio TMED9 Transmembrane emp24 domain-containing protein 9

Protein Summary

Description

Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer-dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 isoform PTPB. This gene is a member of a family of genes encoding transport proteins located in the endoplasmic reticulum and the Golgi. A similar gene in mouse is the target of microRNA miR-296, which is part of an imprinted cluster. [provided by RefSeq, Jul 2016]

Uniprot Accession IDs

• Q9BVK6
• Q14437
• Q8WZ61

Gene Name

• TMED9

Ensembl ID

• ENST00000332598
• ENSP00000330945
• ENSG00000184840

Symbol

• GP25L2
• p25
• GMP25
• p24a2
• HSGP25L2G
• p24alpha2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.99
transcription factor perturbation	0.88
interacting protein	0.87
cellular component	0.86
transcription factor binding site profile	0.82

Protein Classes

PANTHER Classes

Protein / Transfer/carrier Protein / Transmembrane Emp24 Domain-containing Protein 9

Protein / Membrane Traffic Protein / Vesicle Coat Protein / Transmembrane Emp24 Domain-containing Protein 9

DTO Classes

Protein / Transporter / Vesicle Coat Protein / Transmembrane Emp24 Domain-containing Protein 9

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.13   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 146   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.13   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0