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Tdark
TMED4
Transmembrane emp24 domain-containing protein 4

Protein Summary
Description
Involved in vesicular protein trafficking, mainly in the early secretory pathway. targeting. Involved in the maintenance of the Golgi apparatus. Appears to play a role in the biosynthesis of secreted cargo including processing. Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock response and apoptosis (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000457408
  • ENSP00000404042
  • ENSG00000158604
  • ENST00000481238
  • ENSP00000417443

Symbol
  • ERS25
  • HNLF
  • ERS25
  • p24a3
  • GMP25iso
  • p24alpha3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
disease perturbation
0.9
histone modification site profile
0.9
transcription factor perturbation
0.8
cell type or tissue
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.47   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 132   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.47   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 132   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (39)
TMED7
Tdark
Novelty:  0.31193294
p_int:  0.999994302
p_ni:  0.000005697
p_wrong:  1e-9
Score:  0.465
Data Source:  BioPlex,STRINGDB
TMED2
Tbio
Novelty:  0.03731104
p_int:  0.999985745
p_ni:  0.000014255
Score:  0.983
Data Source:  BioPlex,STRINGDB
LIPG
Tchem
Family:  Enzyme
Novelty:  0.00412129
p_int:  0.99994887
p_ni:  0.00005113
Score:  0.613
Data Source:  BioPlex,STRINGDB
TMED10
Tbio
Novelty:  0.02742083
p_int:  0.999731581
p_ni:  0.000268419
Score:  0.994
Data Source:  BioPlex,STRINGDB
SCN3B
Tbio
Family:  IC
Novelty:  0.0438123
p_int:  0.999453042
p_ni:  0.000546956
p_wrong:  2e-9
Data Source:  BioPlex
NUP62
Tbio
Novelty:  0.01432724
p_int:  0.995231622
p_ni:  0.004768378
Data Source:  BioPlex
TMED3
Tbio
Novelty:  0.06696993
p_int:  0.993416735
p_ni:  0.006583265
Score:  0.888
Data Source:  BioPlex,STRINGDB
CDK5RAP3
Tbio
Novelty:  0.03628071
p_int:  0.992486808
p_ni:  0.007513192
Score:  0.185
Data Source:  BioPlex,STRINGDB
FGF3
Tbio
Novelty:  0.00474087
p_int:  0.989200473
p_ni:  0.010799527
Data Source:  BioPlex
CHST8
Tbio
Family:  Enzyme
Novelty:  0.03489772
p_int:  0.987416855
p_ni:  0.012583145
p_wrong:  1e-9
Score:  0.159
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
9
9
19
99.1
total cholesterol measurement
6
6
8
89.8
hip bone size
1
1
1
54.4
apolipoprotein B measurement
1
1
1
41.8
HMG CoA reductase inhibitor use measurement
1
1
1
8.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
19
99.1
total cholesterol measurement
8
89.8
hip bone size
1
54.4
apolipoprotein B measurement
1
41.8
HMG CoA reductase inhibitor use measurement
1
8.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane p24 trafficking protein 4
VGNC:8783
463382
Macaque
transmembrane p24 trafficking protein 4
699105
Mouse
MGI:1915070
103694
Dog
transmembrane p24 trafficking protein 4
VGNC:47439
475498
Horse
transmembrane p24 trafficking protein 4
VGNC:24169
100065195
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane p24 trafficking protein 4
Macaque
transmembrane p24 trafficking protein 4
Mouse
Dog
transmembrane p24 trafficking protein 4
Horse
transmembrane p24 trafficking protein 4
Publication Statistics
PubMed Score 4.47
PubMed score by year
PubTator Score 1.65
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title