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Tbio
TMED1
Transmembrane emp24 domain-containing protein 1

Protein Summary
Description
Potential role in vesicular protein trafficking, mainly in the early secretory pathway. May act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side. This gene belongs to the TMED (transmembrane emp24 domain-containing) protein family, which is involved in the vesicular trafficking of proteins. The protein encoded by this gene was identified by its interaction with interleukin 1 receptor-like 1 (IL1RL1) and may play a role in innate immunity. This protein lacks any similarity to other interleukin 1 ligands. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000214869
  • ENSP00000214869
  • ENSG00000099203

Symbol
  • IL1RL1L
  • IL1RL1LG
  • Tp24
  • p24g1
  • Il1rl1l
  • IL1RL1LG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
histone modification site profile
0.95
interacting protein
0.82
transcription factor binding site profile
0.81
cell type or tissue
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.89   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 159   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.89   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (25)
SPPL2B
Tchem
Family:  Enzyme
Novelty:  0.0274774
p_int:  0.99386343
p_ni:  0.00613657
Score:  0.153
Data Source:  BioPlex,STRINGDB
TMED2
Tbio
Novelty:  0.03731104
p_int:  0.992742949
p_ni:  0.00725705
p_wrong:  1e-9
Score:  0.553
Data Source:  BioPlex,STRINGDB
FGF3
Tbio
Novelty:  0.00474087
p_int:  0.971765116
p_ni:  0.028234884
Score:  0.177
Data Source:  BioPlex,STRINGDB
TMED10
Tbio
Novelty:  0.02742083
p_int:  0.970868384
p_ni:  0.029131616
Score:  0.941
Data Source:  BioPlex,STRINGDB
CDK5RAP3
Tbio
Novelty:  0.03628071
p_int:  0.963967459
p_ni:  0.036032541
Score:  0.21
Data Source:  BioPlex,STRINGDB
JPH4
Tbio
Novelty:  0.07699598
p_int:  0.769644162
p_ni:  0.230355838
Data Source:  BioPlex
TMED9
Tbio
Novelty:  0.24024246
Score:  0.822
Data Source:  STRINGDB
TMED4
Tdark
Novelty:  0.22372593
Score:  0.804
Data Source:  STRINGDB
IL1RL1
Tbio
Novelty:  0.00541949
Score:  0.759
Data Source:  STRINGDB
CYB5R4
Tbio
Family:  Enzyme
Novelty:  0.06424571
Score:  0.578
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
6
7
98.8
total cholesterol measurement
2
5
6
98.1
apolipoprotein B measurement
1
4
4
98
IGF-1 measurement
1
3
3
89.9
C-reactive protein measurement
2
1
2
46.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
7
98.8
total cholesterol measurement
6
98.1
apolipoprotein B measurement
4
98
IGF-1 measurement
3
89.9
C-reactive protein measurement
2
46.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane p24 trafficking protein 1
VGNC:2227
455719
Macaque
transmembrane p24 trafficking protein 1
713618
Mouse
MGI:106201
17083
Rat
RGD:1311679
315461
Dog
transmembrane p24 trafficking protein 1
VGNC:47436
484948
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane p24 trafficking protein 1
Macaque
transmembrane p24 trafficking protein 1
Mouse
Rat
Dog
transmembrane p24 trafficking protein 1
Publication Statistics
PubMed Score 8.89
PubMed score by year
PubTator Score 2.33
PubTator score by year
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Related Publications
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PMID
Year
Title