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Tdark
TMCO3
Transmembrane and coiled-coil domain-containing protein 3

Protein Summary
Description
Probable Na(+)/H(+) antiporter. This gene encodes a member of the monovalent cation:proton antiporter 2 (CPA2) family of transporter proteins. Members of this family typically couple the export of monovalent cations, such as potassium or sodium, to the import of protons across cellular membranes. Mutations in this gene have been identified in patients with a rare inherited vision defect, cornea guttata with anterior polar cataract. [provided by RefSeq, Mar 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375391
  • ENSP00000364540
  • ENSG00000150403
  • ENST00000434316
  • ENSP00000389399
  • ENST00000474393
  • ENSP00000484053

Symbol
  • C13orf11
  • C13orf11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
histone modification site profile
0.79
transcription factor binding site profile
0.74
kinase perturbation
0.71
transcription factor
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.69   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 62   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.69   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 62   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0