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Tdark
TMCC3
Transmembrane and coiled-coil domain protein 3

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261226
  • ENSP00000261226
  • ENSG00000057704

Symbol
  • KIAA1145
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.9
transcription factor perturbation
0.84
tissue sample
0.73
transcription factor binding site profile
0.69
kinase perturbation
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.03   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 89   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.03   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 89   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (35)
TEX28
Tdark
Novelty:  0.10581423
p_int:  0.999999981
p_ni:  1e-9
p_wrong:  1.8e-8
Score:  0.733
Data Source:  BioPlex,STRINGDB
ATP6V0A2
Tbio
Family:  Enzyme
Novelty:  0.00504614
p_int:  0.999999109
p_ni:  8.91e-7
Score:  0.184
Data Source:  BioPlex,STRINGDB
FBXO28
Tbio
Novelty:  0.10548865
p_int:  0.999993816
p_ni:  0.00000458
p_wrong:  0.000001605
Score:  0.647
Data Source:  BioPlex,STRINGDB
CYB5B
Tbio
Novelty:  0.09395308
p_int:  0.996723132
p_ni:  0.000201199
p_wrong:  0.003075669
Data Source:  BioPlex
TMTC4
Tdark
Novelty:  0.53734704
Score:  0.765
Data Source:  STRINGDB
TMEM125
Tdark
Novelty:  2.29727906
Score:  0.718
Data Source:  STRINGDB
CLCA4
Tbio
Family:  IC
Novelty:  0.05891943
Score:  0.625
Data Source:  STRINGDB
EDIL3
Tbio
Novelty:  0.00848858
Score:  0.623
Data Source:  STRINGDB
PRICKLE1
Tbio
Novelty:  0.03175916
Score:  0.61
Data Source:  STRINGDB
UNC79
Tbio
Novelty:  0.05623462
Score:  0.566
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
2
2
66.6
hemoglobin measurement
1
1
1
46.1
mathematical ability
1
1
1
1.4
gut microbiome measurement
1
1
2
1.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
66.6
hemoglobin measurement
1
46.1
mathematical ability
1
1.4
gut microbiome measurement
2
1.1
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane and coiled-coil domain family 3
VGNC:5626
737353
Macaque
transmembrane and coiled-coil domain family 3
716185
Mouse
MGI:2442900
319880
Rat
RGD:1307241
314751
Dog
transmembrane and coiled-coil domain family 3
VGNC:47430
482607
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane and coiled-coil domain family 3
Macaque
transmembrane and coiled-coil domain family 3
Mouse
Rat
Dog
transmembrane and coiled-coil domain family 3
Publication Statistics
PubMed Score 3.03
PubMed score by year
PubTator Score 1.07
PubTator score by year
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Related Publications
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PMID
Year
Title