TMC6
Transmembrane channel-like protein 6
Protein Summary
Probable ion channel. Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 10 transmembrane domains and 2 leucine zipper motifs. [provided by RefSeq, Jul 2008]
- ENST00000306591
- ENSP00000306405
- ENSG00000141524
- ENST00000322914
- ENSP00000313408
- ENST00000392467
- ENSP00000376260
- ENST00000589553
- ENSP00000465359
- ENST00000590602
- ENSP00000465261
- ENST00000591436
- ENSP00000464853
- EVER1
- EVIN1
- EV1
- EVER1
- EVIN1
- LAK-4P
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.92 | ||
cellular component | 0.87 | ||
transcription factor | 0.74 | ||
cell type or tissue | 0.66 | ||
kinase perturbation | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 491.63 (req: < 5)
Gene RIFs: 20 (req: <= 3)
Antibodies: 131 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 491.63 (req: >= 5)
Gene RIFs: 20 (req: > 3)
Antibodies: 131 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0