Tbio TMC5 Transmembrane channel-like protein 5

Protein Summary

Description

Probable ion channel.

Uniprot Accession IDs

• Q6UXY8
• Q68DK8
• Q8IY20
• Q8NHV6
• Q9H8I7

Gene Name

• TMC5

Ensembl ID

• ENST00000219821
• ENSP00000219821
• ENSG00000103534
• ENST00000381414
• ENSP00000370822
• ENST00000396229
• ENSP00000379531
• ENST00000542583
• ENSP00000446274
• ENST00000561503
• ENSP00000456148

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.74
kinase perturbation	0.71
PubMedID	0.62
tissue	0.61
virus perturbation	0.59

Protein Classes

DTO Classes

Protein / Ion Channel / Transmembrane Channel (Tmc) Family / Transmembrane Channel-like Protein 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.25   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 68   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.25   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 68   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0