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Tdark
TMC3
Transmembrane channel-like protein 3

Protein Summary
Description
Probable ion channel.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359440
  • ENSP00000352413
  • ENSG00000188869
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.69
PubMedID
0.62
phenotype
0.59
virus perturbation
0.55
cell type or tissue
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.19   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 13   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.19   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 13   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (21)
TLNRD1
Tdark
Novelty:  0.26211075
Score:  0.768
Data Source:  STRINGDB
MESD
Tbio
Novelty:  0.02639297
Score:  0.681
Data Source:  STRINGDB
ZNF343
Tdark
Family:  TF
Novelty:  1.58167416
Score:  0.669
Data Source:  STRINGDB
CFAP161
Tdark
Novelty:  1.37101386
Score:  0.659
Data Source:  STRINGDB
CLCC1
Tbio
Family:  IC
Novelty:  0.06584842
Score:  0.574
Data Source:  STRINGDB
CCDC82
Tdark
Novelty:  0.48211191
Score:  0.539
Data Source:  STRINGDB
C7orf50
Tbio
Novelty:  0.17956544
Score:  0.491
Data Source:  STRINGDB
TSHZ3
Tbio
Family:  TF
Novelty:  0.02963612
Score:  0.483
Data Source:  STRINGDB
ADCK1
Tchem
Family:  Kinase
Novelty:  0.31158074
Score:  0.48
Data Source:  STRINGDB
ZZEF1
Tdark
Novelty:  0.33216648
Score:  0.473
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
2
2
0
1.1
94.9
interleukin 16 measurement
3
3
3
94.8
pro‐interleukin‐16 measurement
1
2
2
93.8
blood protein measurement
1
1
1
90.8
lymphocyte count
3
1
3
62.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
0
1.1
94.9
interleukin 16 measurement
3
94.8
pro‐interleukin‐16 measurement
2
93.8
blood protein measurement
1
90.8
lymphocyte count
3
62.8
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane channel like 3
VGNC:1870
453589
Macaque
transmembrane channel like 3
718003
Mouse
MGI:2669033
233424
Rat
RGD:1308063
293065
Dog
transmembrane channel like 3
VGNC:47422
488760
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane channel like 3
Macaque
transmembrane channel like 3
Mouse
Rat
Dog
transmembrane channel like 3
Publication Statistics
PubMed Score 5.19
PubMed score by year
PubTator Score 3.20
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title