Tdark TMC3 Transmembrane channel-like protein 3

Protein Summary

Description

Probable ion channel.

Uniprot Accession IDs

• Q7Z5M5
• A2RTY2
• B2RXJ3
• Q7Z405

Gene Name

• TMC3

Ensembl ID

• ENST00000359440
• ENSP00000352413
• ENSG00000188869

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.69
PubMedID	0.62
phenotype	0.59
virus perturbation	0.55
cell type or tissue	0.52

Protein Classes

DTO Classes

Protein / Ion Channel / Transmembrane Channel (Tmc) Family / Transmembrane Channel-like Protein 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.19   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 13   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.19   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 13   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0