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Tbio
TMC2
Transmembrane channel-like protein 2

Protein Summary
Description
Probable ion channel required for the normal function of cochlear hair cells (PubMed:11850618). Component of the hair cell's mechanotransduction (MET) machinery. Involved in mechanosensitive responses of the hair cells (By similarity). This gene encodes a transmembrane protein that is necesssary for mechanotransduction in cochlear hair cells of the inner ear. Mutations in this gene may underlie hereditary disorders of balance and hearing. [provided by RefSeq, Aug 2015]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.76
tissue
0.54
cell line
0.52
gene perturbation
0.5
cell type or tissue
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (48)
TMIE
Tbio
Novelty:  0.02939225
Score:  0.882
Data Source:  STRINGDB
LHFPL5
Tbio
Novelty:  0.03689538
Score:  0.855
Data Source:  STRINGDB
PCDH15
Tbio
Novelty:  0.0097699
Score:  0.775
Data Source:  STRINGDB
DTWD1
Tdark
Novelty:  0.53044591
Score:  0.762
Data Source:  STRINGDB
STT3A
Tbio
Family:  Enzyme
Novelty:  0.01063504
Score:  0.756
Data Source:  STRINGDB
ASIC4
Tbio
Family:  IC
Novelty:  0.02912816
Score:  0.692
Data Source:  STRINGDB
CDH23
Tbio
Novelty:  0.00588227
Score:  0.687
Data Source:  STRINGDB
SLC6A5
Tchem
Family:  Transporter
Novelty:  0.00387587
Score:  0.665
Data Source:  STRINGDB
PIEZO2
Tbio
Family:  IC
Novelty:  0.00731622
Score:  0.648
Data Source:  STRINGDB
PIEZO1
Tchem
Family:  IC
Novelty:  0.00374633
Score:  0.622
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane channel like 2
VGNC:6283
458045
Macaque
transmembrane channel like 2
718161
Mouse
MGI:2151017
192140
Rat
RGD:1310073
296153
Dog
transmembrane channel like 2
VGNC:47421
477179
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane channel like 2
Macaque
transmembrane channel like 2
Mouse
Rat
Dog
transmembrane channel like 2
Publication Statistics
PubMed Score 30.00
PubMed score by year
PubTator Score 12.08
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title