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Tbio
TMBIM4
Protein lifeguard 4

Protein Summary
Description
Anti-apoptotic protein which can inhibit apoptosis induced by intrinsic and extrinsic apoptotic stimuli. Can modulate both capacitative Ca2+ entry and inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ release.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358230
  • ENSP00000350965
  • ENSG00000155957

Symbol
  • GAAP
  • LFG4
  • S1R
  • GAAP
  • LFG4
  • ZPRO
  • CGI-119
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
transcription factor binding site profile
0.87
transcription factor perturbation
0.84
gene perturbation
0.76
histone modification site profile
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 163.64   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 103   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 163.64   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
TMEM97
Tchem
Novelty:  0.00597439
Score:  0.74
Data Source:  STRINGDB
PREP
Tchem
Family:  Enzyme
Novelty:  0.00148266
Score:  0.731
Data Source:  STRINGDB
RCN2
Tbio
Novelty:  0.03883858
Score:  0.672
Data Source:  STRINGDB
TACC3
Tbio
Novelty:  0.00708723
Score:  0.64
Data Source:  STRINGDB
SPACA9
Tdark
Novelty:  1.56900253
Score:  0.634
Data Source:  STRINGDB
KCNQ5
Tclin
Family:  IC
Novelty:  0.01271842
Score:  0.629
Data Source:  STRINGDB
GHITM
Tbio
Novelty:  0.00360652
Score:  0.627
Data Source:  STRINGDB
DENND5B
Tbio
Novelty:  1.22445822
Score:  0.621
Data Source:  STRINGDB
KCNH6
Tclin
Family:  IC
Novelty:  0.01126636
Score:  0.62
Data Source:  STRINGDB
SUOX
Tbio
Family:  Enzyme
Novelty:  0.00971136
Score:  0.62
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
3
3
3
86.6
waist-hip ratio
3
3
3
85.2
BMI-adjusted hip circumference
1
4
4
77.6
hip circumference
1
1
1
29
body height
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
3
86.6
waist-hip ratio
3
85.2
BMI-adjusted hip circumference
4
77.6
hip circumference
1
29
body height
1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane BAX inhibitor motif containing 4
VGNC:13468
452056
Macaque
transmembrane BAX inhibitor motif containing 4
717825
Mouse
MGI:1915462
68212
Rat
RGD:735173
362884
Dog
transmembrane BAX inhibitor motif containing 4
474432
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane BAX inhibitor motif containing 4
Macaque
transmembrane BAX inhibitor motif containing 4
Mouse
Rat
Dog
transmembrane BAX inhibitor motif containing 4
Publication Statistics
PubMed Score 163.64
PubMed score by year
PubTator Score 44.29
PubTator score by year
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Related Publications
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PMID
Year
Title