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Tbio
TM4SF18
Transmembrane 4 L6 family member 18

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296059
  • ENSP00000296059
  • ENSG00000163762
  • ENST00000470080
  • ENSP00000419278

Symbol
  • L6D
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.63
tissue sample
0.58
tissue
0.42
PubMedID
0.36
cell line
0.34


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.97   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.97   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (20)
TMEM65
Tdark
Novelty:  0.35968506
p_int:  0.999997614
p_ni:  4.4e-8
p_wrong:  0.000002342
Score:  0.379
Data Source:  BioPlex,STRINGDB
CD320
Tbio
Novelty:  0.01978884
p_int:  0.996338439
p_ni:  0.003661364
p_wrong:  1.98e-7
Score:  0.165
Data Source:  BioPlex,STRINGDB
STXBP1
Tbio
Novelty:  0.00339098
p_int:  0.993157709
p_ni:  0.006842291
Score:  0.189
Data Source:  BioPlex,STRINGDB
TMEM179B
Tdark
Novelty:  19.38461538
p_int:  0.96532924
p_ni:  0.000578499
p_wrong:  0.034092261
Score:  0.404
Data Source:  BioPlex,STRINGDB
CD47
Tchem
Novelty:  0.00129086
p_int:  0.927090654
p_ni:  0.072909
p_wrong:  3.46e-7
Score:  0.189
Data Source:  BioPlex,STRINGDB
REEP5
Tbio
Novelty:  0.00160455
p_int:  0.918402364
p_ni:  0.081597622
p_wrong:  1.4e-8
Data Source:  BioPlex
TM4SF20
Tbio
Novelty:  0.21582226
Score:  0.675
Data Source:  STRINGDB
FAM189A2
Tdark
Novelty:  0.41335428
Score:  0.606
Data Source:  STRINGDB
TMEM121
Tdark
Novelty:  0.18541234
Score:  0.583
Data Source:  STRINGDB
ADAL
Tbio
Family:  Enzyme
Novelty:  0.02192886
Score:  0.497
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
1
1
13.1
low density lipoprotein cholesterol measurement
1
1
1
1.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
13.1
low density lipoprotein cholesterol measurement
1
1.5
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane 4 L six family member 18
VGNC:2606
460769
Dog
transmembrane 4 L six family member 18
VGNC:47407
477107
Horse
transmembrane 4 L six family member 18
VGNC:24141
100058490
Cow
transmembrane 4 L six family member 18
VGNC:35904
507280
Opossum
transmembrane 4 L six family member 18
100012360
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane 4 L six family member 18
Dog
transmembrane 4 L six family member 18
Horse
transmembrane 4 L six family member 18
Cow
transmembrane 4 L six family member 18
Opossum
transmembrane 4 L six family member 18
Publication Statistics
PubMed Score 5.97
PubMed score by year
PubTator Score 0.33
PubTator score by year
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Related Publications
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PMID
Year
Title