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Tdark
TM2D2
TM2 domain-containing protein 2

Protein Summary
Description
The protein encoded by this gene contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily. This protein has sequence and structural similarities to the beta-amyloid binding protein (BBP), but, unlike BBP, it does not regulate a response to beta-amyloid peptide. This protein may have regulatory roles in cell death or proliferation signal cascades. This gene has multiple alternatively spliced transcript variants which encode two different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397070
  • ENSP00000380260
  • ENSG00000169490
  • ENST00000456397
  • ENSP00000416050
  • ENST00000456845
  • ENSP00000391674

Symbol
  • BLP1
  • BLP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
transcription factor perturbation
0.88
disease perturbation
0.79
cell type or tissue
0.72
virus perturbation
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.03   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 32   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.03   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 32   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (38)
TM2D3
Tbio
Novelty:  0.09408834
p_int:  0.999878735
p_ni:  0.000121262
p_wrong:  3e-9
Score:  0.372
Data Source:  BioPlex,STRINGDB
SIDT2
Tbio
Novelty:  0.07560652
p_int:  0.999811881
p_ni:  0.000188108
p_wrong:  1.1e-8
Data Source:  BioPlex
UQCC1
Tbio
Family:  Enzyme
Novelty:  0.03937066
p_int:  0.998189164
p_ni:  0.001810836
Score:  0.311
Data Source:  BioPlex,STRINGDB
TMEM97
Tchem
Novelty:  0.00597439
p_int:  0.967204739
p_ni:  0.032794853
p_wrong:  4.08e-7
Score:  0.189
Data Source:  BioPlex,STRINGDB
PCNX3
Tdark
Novelty:  0.76597717
p_int:  0.960016893
p_ni:  0.039983107
Score:  0.173
Data Source:  BioPlex,STRINGDB
UQCC2
Tbio
Family:  Enzyme
Novelty:  0.02059646
p_int:  0.936385084
p_ni:  0.063614916
Score:  0.665
Data Source:  BioPlex,STRINGDB
SLC47A1
Tchem
Family:  Transporter
Novelty:  0.00535064
p_int:  0.926341061
p_ni:  0.073596522
p_wrong:  0.000062417
Data Source:  BioPlex
MBOAT7
Tbio
Family:  Enzyme
Novelty:  0.01861411
p_int:  0.921804911
p_ni:  0.078101739
p_wrong:  0.00009335
Data Source:  BioPlex
PIGM
Tbio
Family:  Enzyme
Novelty:  0.02186069
p_int:  0.88046701
p_ni:  0.119532985
p_wrong:  6e-9
Score:  0.411
Data Source:  BioPlex,STRINGDB
ALG8
Tbio
Family:  Enzyme
Novelty:  0.03721075
p_int:  0.877837782
p_ni:  0.122162053
p_wrong:  1.65e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
1
1
1
47.7
monocyte count
1
1
1
40.7
basophil count
1
1
1
35
sex hormone-binding globulin measurement
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
1
47.7
monocyte count
1
40.7
basophil count
1
35
sex hormone-binding globulin measurement
1
31.4
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TM2 domain containing 2
VGNC:783
464127
Mouse
MGI:1916992
69742
Rat
RGD:1306769
290833
Dog
TM2 domain containing 2
VGNC:47405
482850
Horse
TM2 domain containing 2
VGNC:24138
100058661
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TM2 domain containing 2
Mouse
Rat
Dog
TM2 domain containing 2
Horse
TM2 domain containing 2
Publication Statistics
PubMed Score 10.03
PubMed score by year
PubTator Score 0.50
PubTator score by year
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Related Publications
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PMID
Year
Title