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Tdark
TM2D1
TM2 domain-containing protein 1

Protein Summary
Description
May participate in amyloid-beta-induced apoptosis via its interaction with beta-APP42. The protein encoded by this gene is a beta-amyloid peptide-binding protein. It contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily and known to be important in heterotrimeric G protein activation. Beta-amyloid peptide has been established to be a causative factor in neuron death and the consequent diminution of cognitive abilities observed in Alzheimer's disease. This protein may be a target of neurotoxic beta-amyloid peptide, and may mediate cellular vulnerability to beta-amyloid peptide toxicity through a G protein-regulated program of cell death. Several transcript variants have been found for this gene. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294613
  • ENSP00000294613
  • ENSG00000162604
  • ENST00000606498
  • ENSP00000475700

Symbol
  • BBP
  • BBP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
histone modification site profile
0.86
transcription factor binding site profile
0.69
kinase perturbation
0.54
small molecule perturbation
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.88   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 58   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.88   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 58   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (24)
PCNX3
Tdark
Novelty:  0.76597717
p_int:  0.999982917
p_ni:  0.000017076
p_wrong:  7e-9
Data Source:  BioPlex
TM2D3
Tbio
Novelty:  0.09408834
p_int:  0.999598453
p_ni:  0.000401546
p_wrong:  1e-9
Score:  0.344
Data Source:  BioPlex,STRINGDB
ATG9A
Tbio
Novelty:  0.01995033
p_int:  0.995709741
p_ni:  0.004290232
p_wrong:  2.7e-8
Data Source:  BioPlex
DPY19L4
Tdark
Family:  Enzyme
Novelty:  0.99997412
p_int:  0.97812931
p_ni:  0.021765291
p_wrong:  0.000105399
Data Source:  BioPlex
TM2D2
Tdark
Novelty:  0.10390283
Score:  0.931
Data Source:  STRINGDB
FGGY
Tbio
Family:  Kinase
Novelty:  0.05162577
Score:  0.578
Data Source:  STRINGDB
PAG1
Tbio
Novelty:  0.01390911
Score:  0.535
Data Source:  STRINGDB
FUT11
Tbio
Family:  Enzyme
Novelty:  0.16098097
Score:  0.53
Data Source:  STRINGDB
EVA1B
Tdark
Novelty:  2.1380272
Score:  0.518
Data Source:  STRINGDB
FAM53A
Tdark
Novelty:  0.36536231
Score:  0.507
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
1
1
26.6
myeloid white cell count
1
1
1
9.1
platelet crit
1
1
1
9.1
hip bone size
1
1
1
1
JT interval
1
1
0
14.9
0.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
26.6
myeloid white cell count
1
9.1
platelet crit
1
9.1
hip bone size
1
1
JT interval
0
14.9
0.9
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TM2 domain containing 1
VGNC:1675
456899
Macaque
TM2 domain containing 1
694282
Mouse
MGI:2137022
94043
Rat
RGD:1305442
362545
Dog
TM2 domain containing 1
VGNC:47404
479551
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TM2 domain containing 1
Macaque
TM2 domain containing 1
Mouse
Rat
Dog
TM2 domain containing 1
Publication Statistics
PubMed Score 4.88
PubMed score by year
PubTator Score 4.50
PubTator score by year
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Related Publications
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PMID
Year
Title