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Tbio
TLX3
T-cell leukemia homeobox protein 3

Protein Summary
Description
The protein encoded by this gene is an orphan homeobox protein that encodes a DNA-binding nuclear transcription factor. A translocation [t(5;14)(q35;q32)] involving this gene is associated with T-cell acute lymphoblastic leukemia (T-ALL) in children and young adults. [provided by RefSeq, Nov 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296921
  • ENSP00000296921
  • ENSG00000164438

Symbol
  • HOX11L2
  • RNX
  • HOX11L2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.82
transcription factor
0.63
PubMedID
0.62
protein domain
0.58
transcription factor binding site profile
0.51


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.19   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 141   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.19   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (52)
ARX
Tbio
Family:  TF
Novelty:  0.0080969
Score:  0.787
Data Source:  STRINGDB
LMX1B
Tbio
Family:  TF
Novelty:  0.00405645
Score:  0.763
Data Source:  STRINGDB
PHF6
Tbio
Family:  Epigenetic
Novelty:  0.00958984
Score:  0.761
Data Source:  STRINGDB
LMO1
Tbio
Novelty:  0.01670419
Score:  0.756
Data Source:  STRINGDB
PRDM13
Tbio
Family:  TF; Epigenetic
Novelty:  0.08359319
Score:  0.74
Data Source:  STRINGDB
LHX1
Tbio
Family:  TF
Novelty:  0.01291002
Score:  0.726
Data Source:  STRINGDB
LMO2
Tbio
Novelty:  0.0038279
Score:  0.707
Data Source:  STRINGDB
TAL1
Tbio
Family:  TF
Novelty:  0.00294416
Score:  0.691
Data Source:  STRINGDB
LYL1
Tbio
Family:  TF
Novelty:  0.02669155
Score:  0.679
Data Source:  STRINGDB
NUP214
Tbio
Novelty:  0.00924336
Score:  0.644
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
comparative body size at age 10, self-reported
1
1
1
42.3
mathematical ability
1
1
1
21.5
1
1
1
21.5
cortical surface area measurement
1
1
0
516.5
8.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
comparative body size at age 10, self-reported
1
42.3
mathematical ability
1
21.5
1
21.5
cortical surface area measurement
0
516.5
8.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1351209
27140
Rat
RGD:1564190
497881
Dog
T-cell leukemia homeobox 3
489123
Horse
T-cell leukemia homeobox 3
100059154
Cow
T-cell leukemia homeobox 3
618473
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
T-cell leukemia homeobox 3
Horse
T-cell leukemia homeobox 3
Cow
T-cell leukemia homeobox 3
Publication Statistics
PubMed Score 89.19
PubMed score by year
PubTator Score 43.76
PubTator score by year
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Related Publications
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PMID
Year
Title