Tclin TLR7 Toll-like receptor 7

Protein Summary

Description

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9NYK1
• D1CS69
• Q9NR98

Gene Name

• TLR7

Ensembl ID

• ENST00000380659
• ENSP00000370034
• ENSG00000196664

Symbol

• TLR7-like

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.97
biological process	0.94
protein domain	0.92
phenotype	0.67
disease	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1994.02   (req: < 5)

Gene RIFs: 373   (req: <= 3)

Antibodies: 937   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1994.02   (req: >= 5)

Gene RIFs: 373   (req: > 3)

Antibodies: 937   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 282

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2