Protein Summary
Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852, PubMed:17889651). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also activate immune cells and promote apoptosis in response to the lipid moiety of lipoproteins (PubMed:10426995, PubMed:10426996). Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6 (PubMed:11441107). Stimulation of monocytes in vitro with M.tuberculosis PstS1 induces p38 MAPK and ERK1/2 activation primarily via this receptor, but also partially via TLR4 (PubMed:16622205). MAPK activation in response to bacterial peptidoglycan also occur ...more
- ENST00000260010
- ENSP00000260010
- ENSG00000137462
- ENST00000642580
- ENSP00000495339
- ENST00000642700
- ENSP00000494425
- ENST00000644308
- ENSP00000496321
- TIL4
- TIL4
- CD282
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
biological term | 1 | ||
virus perturbation | 1 | ||
protein domain | 0.85 | ||
disease | 0.84 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4935.44 (req: < 5)
Gene RIFs: 1164 (req: <= 3)
Antibodies: 1225 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4935.44 (req: >= 5)
Gene RIFs: 1164 (req: > 3)
Antibodies: 1225 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 68
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 56
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (56)
Protein-Protein Interactions (555)
STAT5A
Family: TF
Novelty: 0.00074026
p_int: 0.99999948
p_ni: 5.2e-7
Score: 0.531
Data Source: BioPlex,STRINGDB
ACVR2A
Family: Kinase
Novelty: 0.0063932
p_int: 0.944150669
p_ni: 0.055088187
p_wrong: 0.000761144
Score: 0.247
Data Source: BioPlex,STRINGDB
BMPR1A
Family: Kinase
Novelty: 0.00343928
p_int: 0.904940777
p_ni: 0.058923062
p_wrong: 0.036136161
Score: 0.25
Data Source: BioPlex,STRINGDB
ITPRIP
Novelty: 0.27051709
p_int: 0.841237631
p_ni: 0.158762369
Score: 0.179
Data Source: BioPlex,STRINGDB
USP33
Family: Enzyme
Novelty: 0.04411285
p_int: 0.814331969
p_ni: 0.185668003
p_wrong: 2.8e-8
Score: 0.154
Data Source: BioPlex,STRINGDB
STK11IP
Family: Enzyme
Novelty: 0.2856954
p_int: 0.804157927
p_ni: 0.195842073
Score: 0.188
Data Source: BioPlex,STRINGDB
LGR4
Family: GPCR
Novelty: 0.01180123
p_int: 0.77703092
p_ni: 0.221896428
p_wrong: 0.001072652
Score: 0.212
Data Source: BioPlex,STRINGDB
AP1M1
Novelty: 0.029282
p_int: 0.762342178
p_ni: 0.237657822
Score: 0.239
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (7)
Downstream (7)
1 – 5 of 7
PIK3CA
PIK3CD
IL1B
IL12B
Pathways (55)
Reactome (22)
KEGG (19)
PathwayCommons (2)
WikiPathways (12)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Antigen processing-Cross presentation | ||||
Reactome | Antimicrobial peptides | ||||
Reactome | Beta defensins | ||||
Reactome | Class I MHC mediated antigen processing & presentation | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Adaptive Immune System | ||||
Antigen processing-Cross presentation | ||||
Antimicrobial peptides | ||||
Beta defensins | ||||
Class I MHC mediated antigen processing & presentation | ||||
Viral Interactions (0)
Gene Ontology Terms (80)
Functions (11)
Components (12)
Processes (57)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | ARUK-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | ARUK-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
mean reticulocyte volume | 1 | 1 | 1 | 77.3 | |||||
mean corpuscular volume | 1 | 1 | 1 | 61.4 | |||||
reticulocyte measurement | 1 | 1 | 1 | 53.7 | |||||
reticulocyte count | 1 | 1 | 1 | 50.6 | |||||
platelet crit | 1 | 1 | 1 | 49.5 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
mean reticulocyte volume | 1 | 77.3 | |||||
mean corpuscular volume | 1 | 61.4 | |||||
reticulocyte measurement | 1 | 53.7 | |||||
reticulocyte count | 1 | 50.6 | |||||
platelet crit | 1 | 49.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | toll like receptor 2 | VGNC:12860 | 471325 | |||||
Macaque | toll like receptor 2 | 574290 | ||||||
Mouse | MGI:1346060 | 24088 | ||||||
Rat | RGD:735138 | 310553 | ||||||
Dog | toll like receptor 2 | 448807 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | toll like receptor 2 | |||||
Macaque | toll like receptor 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | toll like receptor 2 | |||||
Publication Statistics
PubMed Score 4935.44
PubMed score by year
PubTator Score 2503.50
PubTator score by year
Related Publications
Text Mined References (1334)
GeneRif Annotations (1164)
Items per page:
0 of 0
PMID | Year | Title |
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