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Tchem
TLR2
Toll-like receptor 2

Protein Summary
Description
Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852, PubMed:17889651). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also activate immune cells and promote apoptosis in response to the lipid moiety of lipoproteins (PubMed:10426995, PubMed:10426996). Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6 (PubMed:11441107). Stimulation of monocytes in vitro with M.tuberculosis PstS1 induces p38 MAPK and ERK1/2 activation primarily via this receptor, but also partially via TLR4 (PubMed:16622205). MAPK activation in response to bacterial peptidoglycan also occur ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260010
  • ENSP00000260010
  • ENSG00000137462
  • ENST00000642580
  • ENSP00000495339
  • ENST00000642700
  • ENSP00000494425
  • ENST00000644308
  • ENSP00000496321

Symbol
  • TIL4
  • TIL4
  • CD282
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
virus perturbation
1
protein domain
0.85
disease
0.84


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4935.44   (req: < 5)
Gene RIFs: 1164   (req: <= 3)
Antibodies: 1225   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4935.44   (req: >= 5)
Gene RIFs: 1164   (req: > 3)
Antibodies: 1225   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 68
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 56
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (555)
STAT5A
Tchem
Family:  TF
Novelty:  0.00074026
p_int:  0.99999948
p_ni:  5.2e-7
Score:  0.531
Data Source:  BioPlex,STRINGDB
TMEM214
Tdark
Novelty:  0.32604613
p_int:  0.975242989
p_ni:  0.024757011
Data Source:  BioPlex
ACVR2A
Tchem
Family:  Kinase
Novelty:  0.0063932
p_int:  0.944150669
p_ni:  0.055088187
p_wrong:  0.000761144
Score:  0.247
Data Source:  BioPlex,STRINGDB
BMPR1A
Tchem
Family:  Kinase
Novelty:  0.00343928
p_int:  0.904940777
p_ni:  0.058923062
p_wrong:  0.036136161
Score:  0.25
Data Source:  BioPlex,STRINGDB
ITPRIP
Tdark
Novelty:  0.27051709
p_int:  0.841237631
p_ni:  0.158762369
Score:  0.179
Data Source:  BioPlex,STRINGDB
USP33
Tbio
Family:  Enzyme
Novelty:  0.04411285
p_int:  0.814331969
p_ni:  0.185668003
p_wrong:  2.8e-8
Score:  0.154
Data Source:  BioPlex,STRINGDB
STK11IP
Tdark
Family:  Enzyme
Novelty:  0.2856954
p_int:  0.804157927
p_ni:  0.195842073
Score:  0.188
Data Source:  BioPlex,STRINGDB
LGR4
Tbio
Family:  GPCR
Novelty:  0.01180123
p_int:  0.77703092
p_ni:  0.221896428
p_wrong:  0.001072652
Score:  0.212
Data Source:  BioPlex,STRINGDB
AP1M1
Tbio
Novelty:  0.029282
p_int:  0.762342178
p_ni:  0.237657822
Score:  0.239
Data Source:  BioPlex,STRINGDB
TLR1
Tbio
Novelty:  0.00171909
Score:  0.995
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets (7)
Explore Nearest Tclin Targets
1 – 5 of 7
Pathways (55)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 22
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing-Cross presentation
Reactome
Antimicrobial peptides
Reactome
Beta defensins
Reactome
Class I MHC mediated antigen processing & presentation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing-Cross presentation
Antimicrobial peptides
Beta defensins
Class I MHC mediated antigen processing & presentation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (80)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ARUK-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
77.3
mean corpuscular volume
1
1
1
61.4
reticulocyte measurement
1
1
1
53.7
reticulocyte count
1
1
1
50.6
platelet crit
1
1
1
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
77.3
mean corpuscular volume
1
61.4
reticulocyte measurement
1
53.7
reticulocyte count
1
50.6
platelet crit
1
49.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
toll like receptor 2
VGNC:12860
471325
Macaque
toll like receptor 2
574290
Mouse
MGI:1346060
24088
Rat
RGD:735138
310553
Dog
toll like receptor 2
448807
Species
Name
OMA
EggNOG
Inparanoid
Chimp
toll like receptor 2
Macaque
toll like receptor 2
Mouse
Rat
Dog
toll like receptor 2
Publication Statistics
PubMed Score 4935.44
PubMed score by year
PubTator Score 2503.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title