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Tdark
TLNRD1
Talin rod domain-containing protein 1

Protein Summary
Description
Actin-binding protein which may have an oncogenic function and regulates cell proliferation, migration and invasion in cancer cells. This gene encodes a protein that is regulated by micro RNA MiR-574-3, and is thought to have an oncogenic function in human bladder cancer. A similar gene in mouse is located in a chromosomal region critical for differentiation of mesoderm, which affects embryo patterning and the formation of heart, muscle, blood, skeleton and the urogenital system. The mouse gene is expressed in early development, and in the adult. [provided by RefSeq, Nov 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267984
  • ENSP00000267984
  • ENSG00000140406

Symbol
  • MESDC1
  • MESDC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.67   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 23   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.67   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 23   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (25)
MESD
Tbio
Novelty:  0.02639297
Score:  0.805
Data Source:  STRINGDB
TMC3
Tdark
Family:  IC
Novelty:  0.23776276
Score:  0.768
Data Source:  STRINGDB
CFAP161
Tdark
Novelty:  1.37101386
Score:  0.73
Data Source:  STRINGDB
HIP1R
Tbio
Novelty:  0.02502713
Score:  0.651
Data Source:  STRINGDB
TMCC1
Tbio
Novelty:  0.13345982
Score:  0.585
Data Source:  STRINGDB
SYNM
Tbio
Novelty:  0.01167838
Score:  0.568
Data Source:  STRINGDB
VCL
Tbio
Novelty:  0.00043107
Score:  0.567
Data Source:  STRINGDB
ZBTB5
Tbio
Novelty:  0.50774653
Score:  0.555
Data Source:  STRINGDB
TMEM181
Tbio
Novelty:  0.88502974
Score:  0.553
Data Source:  STRINGDB
CTNNA3
Tbio
Novelty:  0.01472452
Score:  0.545
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (2)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
HGNC
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
43.7
electrocardiography
1
1
1
21.2
gut microbiome measurement
1
1
1
13.5
high density lipoprotein cholesterol measurement
1
1
1
13.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
43.7
electrocardiography
1
21.2
gut microbiome measurement
1
13.5
high density lipoprotein cholesterol measurement
1
13.5
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1891420
80889
Rat
RGD:1311666
308795
Dog
talin rod domain containing 1
VGNC:47403
488764
Horse
talin rod domain containing 1
VGNC:24137
100052999
Cow
talin rod domain containing 1
VGNC:35899
616452
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
talin rod domain containing 1
Horse
talin rod domain containing 1
Cow
talin rod domain containing 1
Publication Statistics
PubMed Score 4.67
PubMed score by year
PubTator Score 1.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title