Protein Summary
As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity (By similarity). This gene encodes a protein related to talin 1, a cytoskeletal protein that plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. This protein has a different pattern of expression compared to talin 1 but, like talin 1, is thought to associate with unique transmembrane receptors to form novel linkages between extracellular matrices and the actin cytoskeleton. [provided by RefSeq, Jul 2008]
- ENST00000561311
- ENSP00000453508
- ENSG00000171914
- KIAA0320
- ILWEQ
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
interacting protein | 0.97 | ||
co-expressed gene | 0.65 | ||
disease perturbation | 0.62 | ||
cell line | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 39.43 (req: < 5)
Gene RIFs: 16 (req: <= 3)
Antibodies: 167 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 39.43 (req: >= 5)
Gene RIFs: 16 (req: > 3)
Antibodies: 167 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (97)
KANK4
Novelty: 0.22871735
p_int: 0.999999873
p_ni: 1.26e-7
p_wrong: 2e-9
Score: 0.361
Data Source: BioPlex,STRINGDB
RGCC
Novelty: 0.02696671
p_int: 0.999999811
p_ni: 1.82e-7
p_wrong: 7e-9
Score: 0.54
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (6)
Upstream (2)
Downstream (4)
1 – 2 of 2
Pathways (97)
KEGG (4)
PathwayCommons (1)
WikiPathways (92)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
KEGG | Platelet activation | ||||
KEGG | Focal adhesion | ||||
KEGG | Human T-cell leukemia virus 1 infection | ||||
KEGG | Rap1 signaling pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Platelet activation | ||||
Focal adhesion | ||||
Human T-cell leukemia virus 1 infection | ||||
Rap1 signaling pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (4)
Components (6)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Non-traceable Author Statement (NAS) | UniProtKB | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
reticulocyte measurement | 3 | 6 | 8 | 97.6 | |||||
reticulocyte count | 7 | 10 | 15 | 95.9 | |||||
heel bone mineral density | 2 | 2 | 3 | 57.1 | |||||
myeloid white cell count | 1 | 1 | 1 | 54.4 | |||||
leukocyte count | 1 | 1 | 1 | 44.2 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
reticulocyte measurement | 8 | 97.6 | |||||
reticulocyte count | 15 | 95.9 | |||||
heel bone mineral density | 3 | 57.1 | |||||
myeloid white cell count | 1 | 54.4 | |||||
leukocyte count | 1 | 44.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | talin 2 | 705008 | ||||||
Mouse | MGI:1917799 | 70549 | ||||||
Rat | RGD:1565416 | 315776 | ||||||
Dog | talin 2 | VGNC:47402 | 478331 | |||||
Horse | talin 2 | VGNC:24136 | 100054133 | |||||
Publication Statistics
PubMed Score 39.43
PubMed score by year
PubTator Score 19.64
PubTator score by year
Related Publications
Text Mined References (31)
GeneRif Annotations (16)
Items per page:
0 of 0
PMID | Year | Title |
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