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Tchem
TLK2
Serine/threonine-protein kinase tousled-like 2

Protein Summary
Description
Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy. This gene encodes a nuclear serine/threonine kinase that was first identified in Arabidopsis. The encoded protein is thought to function in the regulation of chromatin assembly in the S phase of the cell cycle by regulating the levels of a histone H3/H4 chaperone. This protein is associated with double-strand break repair of DNA damage caused by radiation. Pseudogenes of this gene are present on chromosomes 10 and 17. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326270
  • ENSP00000316512
  • ENSG00000146872
  • ENST00000343388
  • ENSP00000340800
  • ENST00000346027
  • ENSP00000275780

Symbol
  • HsHPK
  • MRD57
  • PKU-ALPHA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
virus perturbation
0.99
disease perturbation
0.98
molecular function
0.91
histone modification site profile
0.85


Related Tools
Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.67   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 299   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.67   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 299   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL388978
chemical structure image
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
2
3
95.7
heel bone mineral density
2
3
3
85.8
longevity
1
1
0
9.2
81.4
cognitive function measurement
1
1
1
61.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
95.7
heel bone mineral density
3
85.8
longevity
0
9.2
81.4
cognitive function measurement
1
61.5
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tousled like kinase 2
VGNC:14199
468207
Macaque
tousled like kinase 2
716528
Mouse
MGI:1346023
24086
Rat
RGD:1310907
303592
Dog
tousled like kinase 2
VGNC:47399
490915
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tousled like kinase 2
Macaque
tousled like kinase 2
Mouse
Rat
Dog
tousled like kinase 2
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (16)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (94)
1 – 10 of 94
TLK1
Tchem
Family: Kinase
Novelty: 0.0342719
p_int: 0.999999983
p_ni: 1.7e-8
Score: 0.868
Data Source: BioPlex,STRINGDB
SPATA1
Tdark
p_int: 0.999999843
p_ni: 1.57e-7
Data Source: BioPlex
ASF1A
Tchem
Novelty: 0.02544466
p_int: 0.999999664
p_ni: 3.36e-7
Score: 0.968
Data Source: BioPlex,STRINGDB
ASF1B
Tbio
Novelty: 0.05716701
p_int: 0.999997472
p_ni: 0.000002528
Score: 0.975
Data Source: BioPlex,STRINGDB
RPS27A
Tbio
Novelty: 0.00658124
p_int: 0.997915423
p_ni: 0.002084577
Score: 0.233
Data Source: BioPlex,STRINGDB
CABIN1
Tbio
Novelty: 0.02528794
p_int: 0.962760265
p_ni: 0.01010522
p_wrong: 0.027134515
Score: 0.806
Data Source: BioPlex,STRINGDB
RFPL3
Tbio
Novelty: 0.44520296
p_int: 0.954373222
p_ni: 0.045626778
Score: 0.269
Data Source: BioPlex,STRINGDB
TNNT1
Tbio
Novelty: 0.00072003
p_int: 0.936482399
p_ni: 0.063517532
p_wrong: 6.9e-8
Data Source: BioPlex
IL36A
Tbio
Novelty: 0.03569425
p_int: 0.918005212
p_ni: 0.081994788
Score: 0.157
Data Source: BioPlex,STRINGDB
LHX6
Tbio
Family: TF
Novelty: 0.01603143
p_int: 0.916260409
p_ni: 0.083739591
Score: 0.187
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  17.67

PubMed score by year
PubTator Score  11.8

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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