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Tbio
TLE3
Transducin-like enhancer protein 3

Protein Summary
Description
Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317509
  • ENSP00000319233
  • ENSG00000140332
  • ENST00000440567
  • ENSP00000415057
  • ENST00000451782
  • ENSP00000394717
  • ENST00000557907
  • ENSP00000453107
  • ENST00000557997
  • ENSP00000453083
  • ENST00000558379
  • ENSP00000453435
  • ENST00000558939
  • ENSP00000452871
  • ENST00000559048
  • ENSP00000453760

Symbol
  • KIAA1547
  • ESG
  • ESG3
  • GRG3
  • HsT18976
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
1
transcription factor binding site profile
0.99
transcription factor perturbation
0.99
kinase perturbation
0.93
PubMedID
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.97   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 86   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.97   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (135)
TLE4
Tbio
Novelty:  0.02094922
p_int:  1
Score:  0.901
Data Source:  BioPlex,Reactome,STRINGDB
MYH2
Tbio
Novelty:  0.00365878
p_int:  1
Score:  0.219
Data Source:  BioPlex,STRINGDB
MYH1
Tbio
Novelty:  0.00472973
p_int:  1
Score:  0.21
Data Source:  BioPlex,STRINGDB
MYH4
Tbio
Novelty:  0.00556982
p_int:  0.999999997
p_ni:  2e-9
p_wrong:  2e-9
Score:  0.206
Data Source:  BioPlex,STRINGDB
MYH3
Tbio
Novelty:  0.00544794
p_int:  0.999999993
p_ni:  1e-9
p_wrong:  6e-9
Data Source:  BioPlex
MYH7
Tbio
Novelty:  0.00268092
p_int:  0.99999999
p_ni:  9e-9
p_wrong:  1e-9
Score:  0.179
Data Source:  BioPlex,STRINGDB
ACTA1
Tbio
Novelty:  0.00111813
p_int:  0.999999975
p_ni:  2.4e-8
Score:  0.192
Data Source:  BioPlex,STRINGDB
MYH8
Tbio
Novelty:  0.01020559
p_int:  0.999999967
p_ni:  2e-9
p_wrong:  3.1e-8
Score:  0.199
Data Source:  BioPlex,STRINGDB
MFAP4
Tbio
Novelty:  0.02023782
p_int:  0.999999622
p_ni:  3.79e-7
Data Source:  BioPlex
TLE1
Tbio
Novelty:  0.00594261
p_int:  0.999999286
p_ni:  7.14e-7
Score:  0.901
Data Source:  BioPlex,Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (30)
Deactivation of the beta-catenin transactivating complex (R-HSA-3769402)

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Find Similar Targets
Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deactivation of the beta-catenin transactivating complex
Reactome
Degradation of beta-catenin by the destruction complex
Reactome
ESR-mediated signaling
Reactome
Estrogen-dependent gene expression
Reactome
Formation of the beta-catenin:TCF transactivating complex
Name
Explore in Pharos
Explore in Source
Deactivation of the beta-catenin transactivating complex
Degradation of beta-catenin by the destruction complex
ESR-mediated signaling
Estrogen-dependent gene expression
Formation of the beta-catenin:TCF transactivating complex
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
2
2
81
serum non-albumin protein measurement
1
1
1
79.7
eosinophil count
2
1
2
72.9
blood protein measurement
1
1
1
70.5
eosinophil percentage of leukocytes
1
1
1
66.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
81
serum non-albumin protein measurement
1
79.7
eosinophil count
2
72.9
blood protein measurement
1
70.5
eosinophil percentage of leukocytes
1
66.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transducin like enhancer of split 3
VGNC:6454
467717
Macaque
transducin like enhancer of split 3
698046
Mouse
MGI:104634
21887
Rat
RGD:620292
84424
Dog
transducin like enhancer of split 3
VGNC:47397
487624
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transducin like enhancer of split 3
Macaque
transducin like enhancer of split 3
Mouse
Rat
Dog
transducin like enhancer of split 3
Publication Statistics
PubMed Score 47.97
PubMed score by year
PubTator Score 21.40
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title