Tbio TLE1 Transducin-like enhancer protein 1

Protein Summary

Description

Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.

Uniprot Accession IDs

• Q04724
• A8K495
• Q5T3G4
• Q969V9

Gene Name

• TLE1

Ensembl ID

• ENST00000376499
• ENSP00000365682
• ENSG00000196781

Symbol

• ESG
• ESG1
• GRG1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.94
transcription factor binding site profile	0.88
trait	0.86
protein domain	0.85
PubMedID	0.83

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Cofactor / Transducin-like Enhancer Protein 1

DTO Classes

Protein / Transcription Factor / Transcription Cofactor / Transducin-like Enhancer Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 221.04   (req: < 5)

Gene RIFs: 55   (req: <= 3)

Antibodies: 481   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 221.04   (req: >= 5)

Gene RIFs: 55   (req: > 3)

Antibodies: 481   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0