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Tdark
TLCD2
TLC domain-containing protein 2

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330676
  • ENSP00000331965
  • ENSG00000185561
  • ENST00000611774
  • ENSP00000479301
  • ENSG00000275246
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.92
tissue sample
0.78
microRNA
0.6
histone modification site profile
0.54
tissue
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.15   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.15   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (5)
SLC6A20
Tbio
Family:  Transporter
Novelty:  0.01435823
p_int:  0.997808914
p_ni:  0.002168196
p_wrong:  0.00002289
Data Source:  BioPlex
TSPAN1
Tbio
Novelty:  0.01547855
p_int:  0.896225628
p_ni:  0.001325792
p_wrong:  0.102448579
Data Source:  BioPlex
WDR81
Tbio
Novelty:  0.04564761
Score:  0.791
Data Source:  STRINGDB
CLN8
Tbio
Novelty:  0.01721625
Score:  0.482
Data Source:  STRINGDB
SLC50A1
Tbio
Family:  Transporter
Novelty:  0.04560795
Score:  0.44
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (36)
Items per page:
1 – 5 of 36
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
3
6
7
97.9
serum albumin measurement
3
6
7
97.9
sex hormone-binding globulin measurement
6
3
8
96.6
sex hormone-binding globulin measurement
6
3
8
96.6
calcium measurement
1
4
4
94.9
Items per page:
1 – 5 of 36
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
7
97.9
serum albumin measurement
7
97.9
sex hormone-binding globulin measurement
8
96.6
sex hormone-binding globulin measurement
8
96.6
calcium measurement
4
94.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TLC domain containing 2
VGNC:14198
750419
Mouse
MGI:1917141
380712
Rat
RGD:1562631
497955
Dog
TLC domain containing 2
611258
Cow
TLC domain containing 2
VGNC:35888
506954
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TLC domain containing 2
Mouse
Rat
Dog
TLC domain containing 2
Cow
TLC domain containing 2
Publication Statistics
PubMed Score 3.15
PubMed score by year
PubTator Score 1.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title