Protein Summary
Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. This gene encodes a thiamine-dependent enzyme which plays a role in the channeling of excess sugar phosphates to glycolysis in the pentose phosphate pathway. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]
- ENST00000423516
- ENSP00000391481
- ENSG00000163931
- ENST00000423525
- ENSP00000405455
- ENST00000462138
- ENSP00000417773
- TK
- TKT1
- SDDHD
- HEL107
- HEL-S-48
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein complex | 1 | ||
transcription factor perturbation | 0.96 | ||
hub protein | 0.92 | ||
interacting protein | 0.88 | ||
protein domain | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 312.36 (req: < 5)
Gene RIFs: 28 (req: <= 3)
Antibodies: 217 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 312.36 (req: >= 5)
Gene RIFs: 28 (req: > 3)
Antibodies: 217 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 45
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0