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Tchem
TK2
Thymidine kinase 2, mitochondrial

Protein Summary
Description
Phosphorylates thymidine, deoxycytidine, and deoxyuridine in the mitochondrial matrix. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on TK2 and DGUOK. Widely used as target of antiviral and chemotherapeutic agents. This gene encodes a deoxyribonucleoside kinase that specifically phosphorylates thymidine, deoxycytidine, and deoxyuridine. The encoded enzyme localizes to the mitochondria and is required for mitochondrial DNA synthesis. Mutations in this gene are associated with a myopathic form of mitochondrial DNA depletion syndrome. Alternate splicing results in multiple transcript variants encoding distinct isoforms, some of which lack transit peptide, so are not localized to mitochondria. [provided by RefSeq, Dec 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299697
  • ENSP00000299697
  • ENSG00000166548
  • ENST00000451102
  • ENSP00000414334
  • ENST00000525974
  • ENSP00000434594
  • ENST00000527284
  • ENSP00000435312
  • ENST00000527800
  • ENSP00000433770
  • ENST00000544898
  • ENSP00000440898
  • ENST00000545043
  • ENSP00000438143
  • ENST00000563369
  • ENSP00000463560
  • ENST00000620035
  • ENSP00000483833

Symbol
  • MTTK
  • PEOB3
  • SCA31
  • MTDPS2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
disease perturbation
0.83
kinase perturbation
0.76
transcription factor binding site profile
0.76
virus perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.11   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 65   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.11   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0