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Tbio
TJP2
Tight junction protein ZO-2

Protein Summary
Description
Plays a role in tight junctions and adherens junctions. This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000348208
  • ENSP00000345893
  • ENSG00000119139
  • ENST00000377245
  • ENSP00000366453
  • ENST00000453658
  • ENSP00000392178
  • ENST00000535702
  • ENSP00000442090
  • ENST00000539225
  • ENSP00000438262
  • ENST00000648204
  • ENSP00000497941

Symbol
  • X104
  • ZO2
  • ZO2
  • X104
  • PFIC4
  • DFNA51
  • DUP9q21.11
  • C9DUPq21.11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
hub protein
0.94
transcription factor perturbation
0.88
drug perturbation
0.87
kinase
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 200.35   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 376   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 200.35   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 376   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (117)
ARHGAP12
Tbio
Family:  Enzyme
Novelty:  0.12113722
p_int:  0.999999482
p_ni:  5.18e-7
Data Source:  BioPlex
DCAF15
Tdark
Novelty:  0.13476661
p_int:  0.999993542
p_ni:  0.000006458
Score:  0.193
Data Source:  BioPlex,STRINGDB
SNAI3
Tbio
Family:  TF
Novelty:  0.03022302
p_int:  0.999958846
p_ni:  0.000041154
Score:  0.275
Data Source:  BioPlex,STRINGDB
IFI30
Tbio
Family:  Enzyme
Novelty:  0.00939681
p_int:  0.999724405
p_ni:  0.000275595
Data Source:  BioPlex
NUDT12
Tbio
Family:  Enzyme
Novelty:  0.18740719
p_int:  0.999152163
p_ni:  0.000847835
p_wrong:  1e-9
Score:  0.196
Data Source:  BioPlex,STRINGDB
KBTBD7
Tdark
Novelty:  0.4947466
p_int:  0.989513479
p_ni:  0.01048651
p_wrong:  1.1e-8
Data Source:  BioPlex
JPH4
Tbio
Novelty:  0.07699598
p_int:  0.989029022
p_ni:  0.010970967
p_wrong:  1.1e-8
Score:  0.156
Data Source:  BioPlex,STRINGDB
MAGIX
Tdark
Novelty:  0.38577176
p_int:  0.985046521
p_ni:  0.014940406
p_wrong:  0.000013073
Score:  0.221
Data Source:  BioPlex,STRINGDB
TNNT1
Tbio
Novelty:  0.00072003
p_int:  0.97750096
p_ni:  0.022447889
p_wrong:  0.000051151
Data Source:  BioPlex
CDK15
Tchem
Family:  Kinase
Novelty:  0.3870338
p_int:  0.956823039
p_ni:  0.04317694
p_wrong:  2e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Apoptotic cleavage of cell adhesion proteins
Reactome
Apoptotic cleavage of cellular proteins
Reactome
Apoptotic execution phase
Reactome
Programmed Cell Death
Name
Explore in Pharos
Explore in Source
Apoptosis
Apoptotic cleavage of cell adhesion proteins
Apoptotic cleavage of cellular proteins
Apoptotic execution phase
Programmed Cell Death
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
3
2
3
9.5
86.1
Myopia
2
2
0
5.3
86.1
age at onset
1
1
0
9.5
74.2
red blood cell density measurement
1
1
1
49.5
Abnormality of refraction
1
1
1
27.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
3
9.5
86.1
Myopia
0
5.3
86.1
age at onset
0
9.5
74.2
red blood cell density measurement
1
49.5
Abnormality of refraction
1
27.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tight junction protein 2
VGNC:4877
464514
Macaque
tight junction protein 2
699586
Mouse
MGI:1341872
21873
Rat
RGD:619807
115769
Dog
tight junction protein 2
VGNC:47387
403854
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tight junction protein 2
Macaque
tight junction protein 2
Mouse
Rat
Dog
tight junction protein 2
Publication Statistics
PubMed Score 200.35
PubMed score by year
PubTator Score 116.89
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title