You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TJP1
Tight junction protein ZO-1

Protein Summary
Description
TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates to the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000346128
  • ENSP00000281537
  • ENSG00000104067
  • ENST00000545208
  • ENSP00000441202
  • ENST00000621049
  • ENSP00000484535
  • ENSG00000277401

Symbol
  • ZO1
  • ZO-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
1
protein domain
0.99
virus perturbation
0.99
hub protein
0.96
chemical
0.94


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2939.8   (req: < 5)
Gene RIFs: 140   (req: <= 3)
Antibodies: 387   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2939.8   (req: >= 5)
Gene RIFs: 140   (req: > 3)
Antibodies: 387   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0