Tbio TJAP1 Tight junction-associated protein 1

Protein Summary

Description

This gene encodes a tight junction-associated protein. Incorporation of the encoded protein into tight junctions occurs at a late stage of formation of the junctions. The encoded protein localizes to the Golgi and may function in vesicle trafficking. Alternatively spliced transcript variants have been described. A related pseudogene exists on the X chromosome. [provided by RefSeq, Mar 2009]

Uniprot Accession IDs

• Q5JTD0
• Q05BH9
• Q5JTD1
• Q5JWW1
• Q68DB2
• Q6P2P3
• Q9H7V7

Gene Name

• TJAP1

Ensembl ID

• ENST00000259751
• ENSP00000259751
• ENSG00000137221
• ENST00000372444
• ENSP00000361521
• ENST00000372445
• ENSP00000361522
• ENST00000372449
• ENSP00000361527
• ENST00000372452
• ENSP00000361530
• ENST00000436109
• ENSP00000407080
• ENST00000438588
• ENSP00000408769
• ENST00000612912
• ENSP00000484142

Symbol

• PILT
• TJP4
• PILT
• TJP4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.98
kinase perturbation	0.88
disease perturbation	0.83
transcription factor	0.8
cell type or tissue	0.67

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.2   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 137   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.2   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0