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Tbio
TJAP1
Tight junction-associated protein 1

Protein Summary
Description
This gene encodes a tight junction-associated protein. Incorporation of the encoded protein into tight junctions occurs at a late stage of formation of the junctions. The encoded protein localizes to the Golgi and may function in vesicle trafficking. Alternatively spliced transcript variants have been described. A related pseudogene exists on the X chromosome. [provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259751
  • ENSP00000259751
  • ENSG00000137221
  • ENST00000372444
  • ENSP00000361521
  • ENST00000372445
  • ENSP00000361522
  • ENST00000372449
  • ENSP00000361527
  • ENST00000372452
  • ENSP00000361530
  • ENST00000436109
  • ENSP00000407080
  • ENST00000438588
  • ENSP00000408769
  • ENST00000612912
  • ENSP00000484142

Symbol
  • PILT
  • TJP4
  • PILT
  • TJP4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
kinase perturbation
0.88
disease perturbation
0.83
transcription factor
0.8
cell type or tissue
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.05   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 137   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.05   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
SYNC
Tbio
Novelty:  0.04605223
p_int:  0.999999865
p_ni:  1.35e-7
Score:  0.186
Data Source:  BioPlex,STRINGDB
FHL3
Tbio
Novelty:  0.11505924
p_int:  0.999999796
p_ni:  2.02e-7
p_wrong:  2e-9
Score:  0.205
Data Source:  BioPlex,STRINGDB
CORO1A
Tbio
Novelty:  0.00898925
p_int:  0.999999707
p_ni:  1.89e-7
p_wrong:  1.04e-7
Score:  0.211
Data Source:  BioPlex,STRINGDB
SYCE1
Tbio
Novelty:  0.05038876
p_int:  0.99999956
p_ni:  4.39e-7
Data Source:  BioPlex
APBA2
Tbio
Novelty:  0.01654185
p_int:  0.999441687
p_ni:  0.000183225
p_wrong:  0.000375088
Score:  0.195
Data Source:  BioPlex,STRINGDB
APBA3
Tbio
Novelty:  0.05059532
p_int:  0.994336315
p_ni:  0.000040774
p_wrong:  0.005622912
Score:  0.18
Data Source:  BioPlex,STRINGDB
MPP2
Tbio
Novelty:  0.0372293
Score:  0.948
Data Source:  STRINGDB
DLG2
Tbio
Novelty:  0.00999909
Score:  0.945
Data Source:  STRINGDB
DXO
Tbio
Family:  Enzyme
Novelty:  0.08260087
Score:  0.902
Data Source:  STRINGDB
DNASE1L2
Tbio
Family:  Enzyme
Novelty:  0.0152658
Score:  0.757
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
1
5
5
83.9
glomerular filtration rate
1
2
2
58.2
mathematical ability
2
1
2
56.6
testosterone measurement
2
2
2
56.2
creatinine measurement
1
2
2
55.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
5
83.9
glomerular filtration rate
2
58.2
mathematical ability
2
56.6
testosterone measurement
2
56.2
creatinine measurement
2
55.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tight junction associated protein 1
VGNC:8571
463194
Macaque
tight junction associated protein 1
700496
Mouse
MGI:1921344
74094
Rat
RGD:1308708
316233
Dog
tight junction associated protein 1
VGNC:47385
481816
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tight junction associated protein 1
Macaque
tight junction associated protein 1
Mouse
Rat
Dog
tight junction associated protein 1
Publication Statistics
PubMed Score 105.05
PubMed score by year
PubTator Score 21.58
PubTator score by year
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Related Publications
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PMID
Year
Title