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Tbio
TIPIN
TIMELESS-interacting protein

Protein Summary
Description
Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress. The protein encoded by this gene is part of the replisome complex, a group of proteins that support DNA replication. It binds TIM, which is involved in circadian rhythm regulation, and aids in protecting cells against DNA damage and stress. Two pseudogenes and two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261881
  • ENSP00000261881
  • ENSG00000075131
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
histone modification site profile
0.91
transcription factor perturbation
0.84
cell type or tissue
0.77
biological process
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.3   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 304   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.3   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 304   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (182)
TIMELESS
Tbio
Novelty:  0.0041528
p_int:  0.999999979
p_ni:  2.1e-8
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
CYP2J2
Tchem
Novelty:  0.00534181
p_int:  0.999996851
p_ni:  0.000002839
p_wrong:  3.1e-7
Data Source:  BioPlex
GINS3
Tbio
Novelty:  0.02892519
p_int:  0.999284341
p_ni:  0.000715659
Score:  0.948
Data Source:  BioPlex,STRINGDB
GINS4
Tbio
Novelty:  0.0316194
p_int:  0.9908102
p_ni:  0.009189796
p_wrong:  4e-9
Score:  0.983
Data Source:  BioPlex,STRINGDB
GINS1
Tbio
Novelty:  0.08722396
p_int:  0.93858721
p_ni:  0.061412787
p_wrong:  3e-9
Score:  0.955
Data Source:  BioPlex,STRINGDB
SUPT16H
Tbio
Family:  Enzyme
Novelty:  0.01026868
p_int:  0.898438627
p_ni:  0.101561373
Score:  0.461
Data Source:  BioPlex,STRINGDB
MCM3
Tbio
Novelty:  0.00593382
p_int:  0.879739879
p_ni:  0.120260121
Score:  0.986
Data Source:  BioPlex,STRINGDB
RPA2
Tbio
Novelty:  0.00879115
Score:  0.999
Data Source:  STRINGDB
RPA1
Tchem
Novelty:  0.00212665
Score:  0.999
Data Source:  STRINGDB
RPA3
Tbio
Novelty:  0.00887858
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
DNA Double-Strand Break Repair (R-HSA-5693532)

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Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Reactome
Homology Directed Repair
Reactome
Processing of DNA double-strand break ends
Name
Explore in Pharos
Explore in Source
DNA Double-Strand Break Repair
DNA Repair
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Homology Directed Repair
Processing of DNA double-strand break ends
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
2
2
68.1
mean platelet volume
2
2
2
68.1
body mass index
1
1
1
55.2
mean corpuscular volume
1
1
1
54.4
1
1
0
1.2
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
68.1
mean platelet volume
2
68.1
body mass index
1
55.2
mean corpuscular volume
1
54.4
0
1.2
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TIMELESS interacting protein
VGNC:1596
453525
Macaque
TIMELESS interacting protein
710328
Mouse
MGI:1921571
66131
Rat
RGD:2323509
100359731
Rat
RGD:1564084
363076
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TIMELESS interacting protein
Macaque
TIMELESS interacting protein
Mouse
Rat
Rat
Publication Statistics
PubMed Score 25.30
PubMed score by year
PubTator Score 14.36
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title