TINAGL1
Tubulointerstitial nephritis antigen-like
Protein Summary
May be implicated in the adrenocortical zonation and in mechanisms for repressing the CYP11B1 gene expression in adrenocortical cells. This is a non catalytic peptidase C1 family protein (By similarity). The protein encoded by this gene is similar in sequence to tubulointerstitial nephritis antigen, a secreted glycoprotein that is recognized by antibodies in some types of immune-related tubulointerstitial nephritis. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
- ENST00000271064
- ENSP00000271064
- ENSG00000142910
- ENST00000457433
- ENSP00000395137
- GIS5
- LCN7
- OLRG2
- TINAGL
- ARG1
- LCN7
- LIECG3
- TINAGRP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.97 | ||
virus | 0.89 | ||
viral protein | 0.8 | ||
transcription factor | 0.77 | ||
small molecule perturbation | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 30 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 177 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 30 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 177 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0