TINAGL1
Tubulointerstitial nephritis antigen-like
Protein Summary
May be implicated in the adrenocortical zonation and in mechanisms for repressing the CYP11B1 gene expression in adrenocortical cells. This is a non catalytic peptidase C1 family protein (By similarity). The protein encoded by this gene is similar in sequence to tubulointerstitial nephritis antigen, a secreted glycoprotein that is recognized by antibodies in some types of immune-related tubulointerstitial nephritis. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
- ENST00000271064
- ENSP00000271064
- ENSG00000142910
- ENST00000457433
- ENSP00000395137
- GIS5
- LCN7
- OLRG2
- TINAGL
- ARG1
- LCN7
- LIECG3
- TINAGRP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.97 | ||
virus | 0.89 | ||
viral protein | 0.8 | ||
transcription factor | 0.77 | ||
small molecule perturbation | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 23.51 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 177 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 23.51 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 177 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (45)
HSPG2
Family: Enzyme
Novelty: 0.00159541
p_int: 0.999999762
p_ni: 1.2e-8
p_wrong: 2.25e-7
Score: 0.591
Data Source: BioPlex,STRINGDB
RIOK1
Family: Kinase
Novelty: 0.02476698
p_int: 0.999879025
p_ni: 0.000120975
Score: 0.198
Data Source: BioPlex,STRINGDB
PRMT5
Family: Epigenetic
Novelty: 0.00395474
p_int: 0.977628696
p_ni: 0.022371304
Score: 0.28
Data Source: BioPlex,STRINGDB
CD59
Novelty: 0.0008352
p_int: 0.955720646
p_ni: 0.003331773
p_wrong: 0.04094758
Score: 0.545
Data Source: BioPlex,STRINGDB
LOXL2
Family: Enzyme
Novelty: 0.00599536
p_int: 0.869958755
p_ni: 0.014962487
p_wrong: 0.115078757
Score: 0.388
Data Source: BioPlex,STRINGDB
GNB2
Novelty: 0.08682553
p_int: 0.863357279
p_ni: 0.136642668
p_wrong: 5.3e-8
Data Source: BioPlex
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (5)
Components (5)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
intelligence | 5 | 15 | 7 | 5.8 | 84.4 | ||||
cognitive function measurement | 3 | 2 | 3 | 68.5 | |||||
self reported educational attainment | 2 | 2 | 1 | 6.1 | 68.1 | ||||
body mass index | 1 | 1 | 1 | 36.5 | |||||
daytime rest measurement | 1 | 1 | 1 | 24.5 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
intelligence | 7 | 5.8 | 84.4 | ||||
cognitive function measurement | 3 | 68.5 | |||||
self reported educational attainment | 1 | 6.1 | 68.1 | ||||
body mass index | 1 | 36.5 | |||||
daytime rest measurement | 1 | 24.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | tubulointerstitial nephritis antigen like 1 | VGNC:8553 | 469260 | |||||
Macaque | tubulointerstitial nephritis antigen like 1 | 705660 | ||||||
Mouse | MGI:2137617 | 94242 | ||||||
Rat | RGD:70956 | 94174 | ||||||
Dog | tubulointerstitial nephritis antigen like 1 | VGNC:47380 | 478155 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | tubulointerstitial nephritis antigen like 1 | |||||
Macaque | tubulointerstitial nephritis antigen like 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | tubulointerstitial nephritis antigen like 1 | |||||
Publication Statistics
PubMed Score 23.51
PubMed score by year
PubTator Score 6.34
PubTator score by year
Related Publications
Text Mined References (27)
GeneRif Annotations (2)
Items per page:
0 of 0
PMID | Year | Title |
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