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Tbio
TINAG
Tubulointerstitial nephritis antigen

Protein Summary
Description
Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. This is a non catalytic peptidase C1 family protein. This gene encodes a glycoprotein that is restricted within the kidney to the basement membranes underlying the epithelium of Bowman's capsule and proximal and distal tubules. Autoantibodies against this protein are found in sera of patients with tubulointerstital nephritis, membranous nephropathy and anti-glomerular basement membrane nephritis. Ontogeny studies suggest that the expression of this antigen is developmentally regulated in a precise spatial and temporal pattern throughout nephrogenesis. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259782
  • ENSP00000259782
  • ENSG00000137251

Symbol
  • TIN-AG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.73
gene perturbation
0.6
cell type or tissue
0.58
protein domain
0.58
kinase perturbation
0.48


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.63   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.63   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (69)
TYW3
Tdark
Novelty:  0.15183348
p_int:  0.999884888
p_ni:  0.000115112
Data Source:  BioPlex
NUDT6
Tbio
Novelty:  0.03648851
p_int:  0.999833612
p_ni:  0.000166343
p_wrong:  4.5e-8
Score:  0.175
Data Source:  BioPlex,STRINGDB
EPDR1
Tbio
Novelty:  0.03597825
p_int:  0.999791095
p_ni:  0.000208874
p_wrong:  3.1e-8
Score:  0.312
Data Source:  BioPlex,STRINGDB
TSHB
Tbio
Novelty:  0.00194403
p_int:  0.998508912
p_ni:  0.001391366
p_wrong:  0.000099722
Score:  0.544
Data Source:  BioPlex,STRINGDB
ACAD11
Tbio
Family:  Enzyme
Novelty:  0.22908145
p_int:  0.997265478
p_ni:  0.002734522
Data Source:  BioPlex
MOCS1
Tclin
Novelty:  0.02785369
p_int:  0.996485196
p_ni:  0.002142175
p_wrong:  0.001372629
Data Source:  BioPlex
CTU2
Tdark
Novelty:  0.00936441
p_int:  0.994865536
p_ni:  0.005134464
Data Source:  BioPlex
BOLA1
Tbio
Novelty:  0.1092583
p_int:  0.990102639
p_ni:  0.000744952
p_wrong:  0.009152409
Data Source:  BioPlex
STK40
Tbio
Family:  Kinase
Novelty:  0.10461675
p_int:  0.989838957
p_ni:  0.010159669
p_wrong:  0.000001374
Score:  0.173
Data Source:  BioPlex,STRINGDB
COP1
Tbio
Family:  Enzyme
Novelty:  0.10908534
p_int:  0.98837619
p_ni:  0.01162381
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
comparative body size at age 10, self-reported
1
1
1
59.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
comparative body size at age 10, self-reported
1
59.5
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tubulointerstitial nephritis antigen
VGNC:8570
462783
Mouse
MGI:1349477
26944
Dog
tubulointerstitial nephritis antigen
VGNC:47379
481848
Horse
tubulointerstitial nephritis antigen
VGNC:24111
100069589
Cow
tubulointerstitial nephritis antigen
VGNC:35874
512517
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tubulointerstitial nephritis antigen
Mouse
Dog
tubulointerstitial nephritis antigen
Horse
tubulointerstitial nephritis antigen
Cow
tubulointerstitial nephritis antigen
Publication Statistics
PubMed Score 25.63
PubMed score by year
PubTator Score 15.99
PubTator score by year
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Related Publications
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PMID
Year
Title