Tbio TIMP1 Metalloproteinase inhibitor 1

Protein Summary

Description

Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P01033
• Q14252
• Q9UCU1

Gene Name

• TIMP1

Ensembl ID

• ENST00000218388
• ENSP00000218388
• ENSG00000102265

Symbol

• CLGI
• TIMP
• EPA
• EPO
• HCI
• CLGI
• TIMP
• TIMP-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	1
kinase perturbation	0.99
chemical	0.98
phenotype	0.91
transcription factor perturbation	0.91

Protein Classes

PANTHER Classes

Protein / ... / Protease Inhibitor / Metalloproteinase Inhibitor 1

DTO Classes

Protein / Enzyme Modulator / Protease Inhibitor / Metalloproteinase Inhibitor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4839.22   (req: < 5)

Gene RIFs: 686   (req: <= 3)

Antibodies: 1007   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4839.22   (req: >= 5)

Gene RIFs: 686   (req: > 3)

Antibodies: 1007   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0