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Tbio
TIMM50
Mitochondrial import inner membrane translocase subunit TIM50

Protein Summary
Description
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo. Isoform 2: May participate in the release of snRNPs and SMN from the Cajal body. This gene encodes a subunit of the TIM23 inner mitochondrial membrane translocase complex. The encoded protein functions as the receptor subunit that recognizes the mitochondrial targeting signal, or presequence, on protein cargo that is destined for the mitochondrial inner membrane and matrix. This protein may also play a role in maintaining the membrane permeability barrier, and knockdown of this gene in human cells results in the release of cytochrome c and apoptosis. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314349
  • ENSP00000318115
  • ENSG00000105197
  • ENST00000544017
  • ENSP00000445806
  • ENST00000607714
  • ENSP00000475531

Symbol
  • TIM50
  • MGCA9
  • TIM50
  • TIM50L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
hub protein
0.99
kinase perturbation
0.93
transcription factor perturbation
0.91
small molecule perturbation
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.62   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 164   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.62   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (144)
ZNF852
Tdark
Family:  TF
Novelty:  1.99122354
p_int:  0.999999194
p_ni:  8.05e-7
Score:  0.199
Data Source:  BioPlex,STRINGDB
WASF1
Tbio
Novelty:  0.00977488
p_int:  0.999996949
p_ni:  0.00000305
Score:  0.243
Data Source:  BioPlex,STRINGDB
ABI2
Tbio
Novelty:  0.02324355
p_int:  0.999981445
p_ni:  0.000018555
Score:  0.571
Data Source:  BioPlex,STRINGDB
ZNF629
Tdark
Family:  TF
Novelty:  0.00907269
p_int:  0.999951491
p_ni:  0.000048509
Score:  0.179
Data Source:  BioPlex,STRINGDB
ZNF724
Tdark
Family:  TF
Novelty:  21.16304348
p_int:  0.9999494
p_ni:  0.00004686
p_wrong:  0.000003741
Score:  0.179
Data Source:  BioPlex,STRINGDB
ZSCAN20
Tdark
Family:  TF
Novelty:  0.37441538
p_int:  0.999931627
p_ni:  0.000068373
Data Source:  BioPlex
WASF3
Tbio
Novelty:  0.0248378
p_int:  0.999926949
p_ni:  0.000072847
p_wrong:  2.04e-7
Score:  0.708
Data Source:  BioPlex,STRINGDB
BRK1
Tbio
Novelty:  0.02289534
p_int:  0.999916664
p_ni:  0.000068868
p_wrong:  0.000014467
Score:  0.552
Data Source:  BioPlex,STRINGDB
MUC5B
Tbio
Novelty:  0.000832
p_int:  0.999881438
p_ni:  0.00011856
p_wrong:  2e-9
Data Source:  BioPlex
WASF2
Tbio
Novelty:  0.00968798
p_int:  0.999850972
p_ni:  0.000149028
Score:  0.173
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Mitochondrial protein import (R-HSA-1268020)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Mitochondrial protein import
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Mitochondrial protein import
Protein localization
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
2
2
77
myeloid white cell count
1
1
1
62.5
leukocyte count
1
1
1
55.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
77
myeloid white cell count
1
62.5
leukocyte count
1
55.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
translocase of inner mitochondrial membrane 50
VGNC:8335
456026
Macaque
translocase of inner mitochondrial membrane 50
697583
Mouse
MGI:1913775
66525
Rat
RGD:1587684
687295
Dog
translocase of inner mitochondrial membrane 50
VGNC:49032
476461
Species
Name
OMA
EggNOG
Inparanoid
Chimp
translocase of inner mitochondrial membrane 50
Macaque
translocase of inner mitochondrial membrane 50
Mouse
Rat
Dog
translocase of inner mitochondrial membrane 50
Publication Statistics
PubMed Score 46.62
PubMed score by year
PubTator Score 14.03
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title