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Tbio
TIMM44
Mitochondrial import inner membrane translocase subunit TIM44

Protein Summary
Description
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source. This gene encodes a peripheral membrane protein associated with the mitochondrial inner membrane translocase, which functions in the import of proteins across the mitochondrial inner membrane and into the mitochondrial matrix. The encoded protein mediates binding of mitochondrial heat shock protein 70 to the translocase of inner mitochondrial membrane 23 (TIM23) complex. Expression of this gene is upregulated in kidney in a mouse model of diabetes. A mutation in this gene is associated with familial oncocytic thyroid carcinoma. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000270538
  • ENSP00000270538
  • ENSG00000104980

Symbol
  • MIMT44
  • TIM44
  • TIM44
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
disease perturbation
0.95
kinase perturbation
0.93
histone modification site profile
0.88
transcription factor binding site profile
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.15   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 53   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.15   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 53   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (163)
TPM2
Tbio
Novelty:  0.00406572
p_int:  0.992822398
p_ni:  0.007177601
p_wrong:  1e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
COL1A1
Tbio
Novelty:  0.00063584
p_int:  0.97106864
p_ni:  0.028931253
p_wrong:  1.08e-7
Score:  0.199
Data Source:  BioPlex,STRINGDB
COL1A2
Tbio
Novelty:  0.00048334
p_int:  0.761560642
p_ni:  0.000018537
p_wrong:  0.238420821
Score:  0.379
Data Source:  BioPlex,STRINGDB
HSPA9
Tchem
Novelty:  0.00235171
Score:  0.999
Data Source:  STRINGDB
GRPEL1
Tbio
Novelty:  0.00185346
Score:  0.999
Data Source:  STRINGDB
TIMM17A
Tbio
Family:  Enzyme
Novelty:  0.02095904
Score:  0.997
Data Source:  STRINGDB
PAM16
Tbio
Family:  Enzyme
Novelty:  0.04932685
Score:  0.997
Data Source:  STRINGDB
TIMM50
Tbio
Family:  Enzyme
Novelty:  0.0238053
Score:  0.995
Data Source:  STRINGDB
TIMM23
Tbio
Family:  Enzyme
Novelty:  0.06463808
Score:  0.995
Data Source:  STRINGDB
DNAJC19
Tbio
Family:  Enzyme
Novelty:  0.02938164
Score:  0.994
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Mitochondrial protein import (R-HSA-1268020)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Mitochondrial protein import
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Mitochondrial protein import
Protein localization
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 2 diabetes mellitus
4
3
2
1
92.6
appendicular lean mass
2
2
2
74.2
sex hormone-binding globulin measurement
4
1
4
70.7
age at menarche
1
1
1
42.8
high density lipoprotein cholesterol measurement
1
1
1
35.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 2 diabetes mellitus
2
1
92.6
appendicular lean mass
2
74.2
sex hormone-binding globulin measurement
4
70.7
age at menarche
1
42.8
high density lipoprotein cholesterol measurement
1
35.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
translocase of inner mitochondrial membrane 44
VGNC:8336
455667
Macaque
translocase of inner mitochondrial membrane 44
709800
Mouse
MGI:1343262
21856
Rat
RGD:3864
29635
Dog
translocase of inner mitochondrial membrane 44
VGNC:49622
485005
Species
Name
OMA
EggNOG
Inparanoid
Chimp
translocase of inner mitochondrial membrane 44
Macaque
translocase of inner mitochondrial membrane 44
Mouse
Rat
Dog
translocase of inner mitochondrial membrane 44
Publication Statistics
PubMed Score 49.15
PubMed score by year
PubTator Score 15.28
PubTator score by year
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Related Publications
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PMID
Year
Title