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Tdark
TIMM29
Mitochondrial import inner membrane translocase subunit Tim29

Protein Summary
Description
Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force. Required for the stability of the TIM22 complex and functions in the assembly of the TIMM22 protein into the TIM22 complex. May facilitate cooperation between TIM22 and TOM complexes by interacting with TOMM40.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000270502
  • ENSP00000270502
  • ENSG00000142444

Symbol
  • c19orf52
  • TIM29
  • C19orf52
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.63   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 25   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.63   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 25   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (66)
TIMM10
Tbio
Family:  Enzyme
Novelty:  0.02727463
p_int:  0.999985485
p_ni:  0.000014515
Score:  0.857
Data Source:  BioPlex,STRINGDB
CHRNA9
Tchem
Family:  IC
Novelty:  0.05009815
p_int:  0.999290992
p_ni:  0.000709008
Data Source:  BioPlex
AGK
Tbio
Family:  Enzyme
Novelty:  0.00919083
p_int:  0.986386317
p_ni:  0.013613683
Score:  0.937
Data Source:  BioPlex,STRINGDB
ALOX15
Tchem
Family:  Enzyme
Novelty:  0.00184734
p_int:  0.959908687
p_ni:  0.037997653
p_wrong:  0.002093659
Score:  0.214
Data Source:  BioPlex,STRINGDB
RBFOX2
Tbio
Novelty:  0.00856339
p_int:  0.948810299
p_ni:  0.051182868
p_wrong:  0.000006833
Data Source:  BioPlex
ATP6V1D
Tbio
Family:  Enzyme
Novelty:  0.02298626
p_int:  0.925599903
p_ni:  0.071597877
p_wrong:  0.00280222
Data Source:  BioPlex
EIF3F
Tbio
Novelty:  0.0319772
p_int:  0.919810399
p_ni:  0.080177016
p_wrong:  0.000012585
Data Source:  BioPlex
CMKLR1
Tchem
Family:  GPCR
Novelty:  0.00893083
p_int:  0.917957192
p_ni:  0.079939548
p_wrong:  0.002103261
Score:  0.186
Data Source:  BioPlex,STRINGDB
FAS
Tbio
Novelty:  0.00043286
p_int:  0.907954224
p_ni:  0.092045776
Data Source:  BioPlex
EDEM2
Tbio
Family:  Enzyme
Novelty:  0.1180208
p_int:  0.891001107
p_ni:  0.108978579
p_wrong:  0.000020314
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
6
11
16
99
total cholesterol measurement
3
9
11
92
apolipoprotein B measurement
2
8
8
91.9
C-reactive protein measurement
4
2
4
62.7
eosinophil count
3
3
3
48.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
16
99
total cholesterol measurement
11
92
apolipoprotein B measurement
8
91.9
C-reactive protein measurement
4
62.7
eosinophil count
3
48.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
translocase of inner mitochondrial membrane 29
VGNC:3655
469058
Mouse
MGI:1917023
69773
Rat
RGD:1309188
315463
Dog
translocase of inner mitochondrial membrane 29
VGNC:49621
611185
Cow
translocase of inner mitochondrial membrane 29
VGNC:49576
508067
Species
Name
OMA
EggNOG
Inparanoid
Chimp
translocase of inner mitochondrial membrane 29
Mouse
Rat
Dog
translocase of inner mitochondrial membrane 29
Cow
translocase of inner mitochondrial membrane 29
Publication Statistics
PubMed Score 3.63
PubMed score by year
PubTator Score 1.33
PubTator score by year
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Related Publications
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PMID
Year
Title