Tbio TIMM10 Mitochondrial import inner membrane translocase subunit Tim10

Protein Summary

Description

Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The mitochondrial protein encoded by this gene belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane, functioning as intermembrane space chaperones for the highly insoluble carrier proteins. [provided by RefSeq, Nov 2011]

Uniprot Accession IDs

• P62072
• A8K136
• Q9WV99
• Q9WVA0
• Q9Y5J8

Gene Name

• TIMM10

Ensembl ID

• ENST00000257245
• ENSP00000257245
• ENSG00000134809
• ENST00000525158
• ENSP00000433627
• ENST00000525587
• ENSP00000435678

Symbol

• TIM10
• TIM10
• TIM10A
• TIMM10A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.89
kinase perturbation	0.88
transcription factor binding site profile	0.84
disease perturbation	0.83
cell type or tissue	0.67

Protein Classes

PANTHER Classes

Protein / Transporter / Mitochondrial Carrier Protein / Mitochondrial Import Inner Membrane Translocase Subunit Tim10

Protein / Transfer/carrier Protein / Mitochondrial Import Inner Membrane Translocase Subunit Tim10

DTO Classes

Mitochondrial Import Inner Membrane Translocase Subunit Tim10 B

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.54   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 87   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.54   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0