Tbio TIMM10 Mitochondrial import inner membrane translocase subunit Tim10

Protein Summary

Description

Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The mitochondrial protein encoded by this gene belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane, functioning as intermembrane space chaperones for the highly insoluble carrier proteins. [provided by RefSeq, Nov 2011]

Uniprot Accession IDs

• P62072
• A8K136
• Q9WV99
• Q9WVA0
• Q9Y5J8

Gene Name

• TIMM10

Ensembl ID

• ENST00000257245
• ENSP00000257245
• ENSG00000134809
• ENST00000525158
• ENSP00000433627
• ENST00000525587
• ENSP00000435678

Symbol

• TIM10
• TIM10
• TIM10A
• TIMM10A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.89
kinase perturbation	0.88
transcription factor binding site profile	0.84
disease perturbation	0.83
cell type or tissue	0.67

Protein Classes

PANTHER Classes

Protein / Transporter / Mitochondrial Carrier Protein / Mitochondrial Import Inner Membrane Translocase Subunit Tim10

Protein / Transfer/carrier Protein / Mitochondrial Import Inner Membrane Translocase Subunit Tim10

DTO Classes

Mitochondrial Import Inner Membrane Translocase Subunit Tim10 B

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.36   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 87   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.36   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (214)

Explore Interacting Targets

1 – 10 of 214

• See Interactions on String-DB

TIMM10B

Tdark

Family:  Enzyme

Novelty:  0.36798313

p_int:  0.999999949

p_ni:  2e-9

p_wrong:  4.9e-8

Score:  0.998

Data Source:  BioPlex,Reactome,STRINGDB

TIMM29

Tdark

Novelty:  0.51321672

p_int:  0.999985485

p_ni:  0.000014515

Score:  0.857

Data Source:  BioPlex,STRINGDB

TIMM9

Tbio

Family:  Enzyme

Novelty:  0.02996764

p_int:  0.999965209

p_ni:  0.000034791

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

ACAD10

Tchem

Family:  Enzyme

Novelty:  0.09858243

p_int:  0.999558883

p_ni:  0.000441117

Data Source:  BioPlex

AGK

Tbio

Family:  Enzyme

Novelty:  0.00919083

p_int:  0.998609195

p_ni:  0.001390805

Score:  0.544

Data Source:  BioPlex,STRINGDB

SUOX

Tbio

Family:  Enzyme

Novelty:  0.00971136

p_int:  0.998270141

p_ni:  0.001578371

p_wrong:  0.000151487

Data Source:  BioPlex

ACAA1

Tbio

Family:  Enzyme

Novelty:  0.00710465

p_int:  0.995815492

p_ni:  0.00418437

p_wrong:  1.38e-7

Data Source:  BioPlex

KIF3A

Tbio

Novelty:  0.00555124

p_int:  0.985219885

p_ni:  0.014780104

p_wrong:  1.1e-8

Data Source:  BioPlex

MTMR6

Tbio

Family:  Enzyme

Novelty:  0.13067072

p_int:  0.982718774

p_ni:  0.01726344

p_wrong:  0.000017786

Data Source:  BioPlex

CHCHD4

Tbio

Novelty:  0.01204944

p_int:  0.9795414

p_ni:  0.0204586

Score:  0.968

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (2)

Reactome (2)

Mitochondrial protein import (R-HSA-1268020)

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1 – 2 of 2

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Mitochondrial protein import	65 targets	R-HSA-1268020
Reactome	Protein localization	165 targets	R-HSA-9609507

Name	Explore in Pharos	Explore in Source
Mitochondrial protein import	65 targets	R-HSA-1268020
Protein localization	165 targets	R-HSA-9609507

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (15)

Functions (5)

Components (6)

Processes (4)

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1 – 5 of 5

GO Term	Evidence	Assigned by
transporter activity	Inferred from Direct Assay (IDA)	BHF-UCL
chaperone binding	Inferred from Physical Interaction (IPI)	BHF-UCL
protein homodimerization activity	Inferred from Physical Interaction (IPI)	BHF-UCL
protein transporter activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
zinc ion binding	Traceable Author Statement (TAS)	UniProtKB

Disease Associations (null)

No disease associations found

GWAS Traits (13)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 13

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	2	2	2		84.1
platelet count	EFO_0004309	1	1	1		66.3
Hodgkins lymphoma	EFO_0000183	1	1	1		51.7
mathematical ability	EFO_0004875	2	1	2		49.5
neuroticism measurement	EFO_0007660	1	2	0	5.8	36.9

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 13

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	2		84.1
platelet count	EFO_0004309	1		66.3
Hodgkins lymphoma	EFO_0000183	1		51.7
mathematical ability	EFO_0004875	2		49.5
neuroticism measurement	EFO_0007660	0	5.8	36.9

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Chaperone
Complete proteome
Disulfide bond
Membrane
Metal-binding
Mitochondrion
Mitochondrion inner membrane
Protein transport
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
cognitive function measurement
Crohn's disease
feeling emotionally hurt measurement
glomerular filtration rate
Hodgkins lymphoma
household income
mathematical ability
mean platelet volume
neuroticism measurement
pappalysin‐1 measurement

IDG Resources

No IDG generated resources found

Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	translocase of inner mitochondrial membrane 10	VGNC:53173	451194
Mouse	translocase of inner mitochondrial membrane 10	MGI:1353429	30059
Rat	translocase of inner mitochondrial membrane 10	RGD:621741	64464
Dog	translocase of inner mitochondrial membrane 10	VGNC:49618	475968
Horse	translocase of inner mitochondrial membrane 10	VGNC:50501	100066829

Species	Name	OMA	EggNOG	Inparanoid
Chimp	translocase of inner mitochondrial membrane 10
Mouse	translocase of inner mitochondrial membrane 10
Rat	translocase of inner mitochondrial membrane 10
Dog	translocase of inner mitochondrial membrane 10
Horse	translocase of inner mitochondrial membrane 10

Publication Statistics

PubMed Score 36.36

PubMed score by year

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PubTator Score 15.44

PubTator score by year

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Related Publications

Text Mined References (17)

GeneRif Annotations (5)

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10

0 of 0

PMID	Year	Title