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Tbio
TIMELESS
Protein timeless homolog

Protein Summary
Description
Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication and in the regulation of the circadian clock. Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock. Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Forms a complex with TIPIN and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress. Timeless promotes TIPIN nuclear localization. Involved in cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. May also play an importa ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229201
  • ENSP00000229201
  • ENSG00000111602
  • ENST00000553532
  • ENSP00000450607

Symbol
  • TIM
  • TIM1
  • TIMELESS1
  • TIM
  • TIM1
  • hTIM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
histone modification site profile
0.91
kinase perturbation
0.81
transcription factor perturbation
0.8
biological process
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 309.76   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 184   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 309.76   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (268)
TIPIN
Tbio
Novelty:  0.03919376
p_int:  0.999999979
p_ni:  2.1e-8
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
FAM9B
Tdark
Novelty:  0.39508009
p_int:  0.999987966
p_ni:  0.000012034
Data Source:  BioPlex
MCM7
Tbio
Novelty:  0.0017984
p_int:  0.999925154
p_ni:  0.000074846
Score:  0.984
Data Source:  BioPlex,STRINGDB
GINS3
Tbio
Novelty:  0.02892519
p_int:  0.999901282
p_ni:  0.000098718
Score:  0.937
Data Source:  BioPlex,STRINGDB
SSRP1
Tbio
Family:  TF
Novelty:  0.0143993
p_int:  0.997550629
p_ni:  0.002449371
Score:  0.735
Data Source:  BioPlex,STRINGDB
MCM3
Tbio
Novelty:  0.00593382
p_int:  0.997203497
p_ni:  0.002796503
Score:  0.987
Data Source:  BioPlex,STRINGDB
H2AFX
Tbio
Novelty:  0.00048694
p_int:  0.994961573
p_ni:  0.005038427
Score:  0.423
Data Source:  BioPlex,STRINGDB
VSIG1
Tbio
Novelty:  0.15442611
p_int:  0.994077386
p_ni:  0.005922614
Data Source:  BioPlex
CD70
Tbio
Novelty:  0.00420393
p_int:  0.991367867
p_ni:  0.008632133
Data Source:  BioPlex
CMKLR1
Tchem
Family:  GPCR
Novelty:  0.00893083
p_int:  0.983038404
p_ni:  0.016812356
p_wrong:  0.00014924
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (44)
DNA Double-Strand Break Repair (R-HSA-5693532)

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Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Reactome
Homology Directed Repair
Reactome
Processing of DNA double-strand break ends
Name
Explore in Pharos
Explore in Source
DNA Double-Strand Break Repair
DNA Repair
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Homology Directed Repair
Processing of DNA double-strand break ends
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (34)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
4
3
4
98.7
amino acid measurement
5
3
8
98.5
metabolite measurement
2
2
2
97
glutamine measurement
4
4
3
35.7
95.8
blood metabolite measurement
4
2
5
95.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
4
98.7
amino acid measurement
8
98.5
metabolite measurement
2
97
glutamine measurement
3
35.7
95.8
blood metabolite measurement
5
95.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
timeless circadian regulator
VGNC:5623
452431
Macaque
timeless circadian regulator
712835
Mouse
MGI:1321393
21853
Rat
RGD:620939
83508
Dog
timeless circadian regulator
VGNC:47375
481112
Species
Name
OMA
EggNOG
Inparanoid
Chimp
timeless circadian regulator
Macaque
timeless circadian regulator
Mouse
Rat
Dog
timeless circadian regulator
Publication Statistics
PubMed Score 309.76
PubMed score by year
PubTator Score 66.84
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title