Tbio TIMD4 T-cell immunoglobulin and mucin domain-containing protein 4

Protein Summary

Description

Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Involved in regulating T-cell proliferation and lymphotoxin signaling. Ligand for HAVCR1/TIMD1 (By similarity).

Uniprot Accession IDs

• Q96H15
• B5MCL9
• TIMD-4

Gene Name

• TIMD4

Ensembl ID

• ENST00000274532
• ENSP00000274532
• ENSG00000145850
• ENST00000407087
• ENSP00000385973

Symbol

• TIM4
• TIM4
• SMUCKLER

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.7
cell line	0.62
gene perturbation	0.62
trait	0.61
protein domain	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 177.99   (req: < 5)

Gene RIFs: 50   (req: <= 3)

Antibodies: 384   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 177.99   (req: >= 5)

Gene RIFs: 50   (req: > 3)

Antibodies: 384   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0