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Tbio
TIMD4
T-cell immunoglobulin and mucin domain-containing protein 4

Protein Summary
Description
Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Involved in regulating T-cell proliferation and lymphotoxin signaling. Ligand for HAVCR1/TIMD1 (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274532
  • ENSP00000274532
  • ENSG00000145850
  • ENST00000407087
  • ENSP00000385973

Symbol
  • TIM4
  • TIM4
  • SMUCKLER
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.7
cell line
0.62
gene perturbation
0.62
trait
0.61
protein domain
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 155.21   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 384   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 155.21   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 384   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (58)
ADGRB1
Tbio
Family:  GPCR
Novelty:  0.01861364
Score:  0.772
Data Source:  STRINGDB
MFGE8
Tbio
Novelty:  0.00132919
Score:  0.738
Data Source:  STRINGDB
STAB2
Tbio
Novelty:  0.01141869
Score:  0.715
Data Source:  STRINGDB
CD300LB
Tbio
Novelty:  0.10587821
Score:  0.699
Data Source:  STRINGDB
GAS6
Tbio
Novelty:  0.00297606
Score:  0.673
Data Source:  STRINGDB
JMJD6
Tchem
Family:  Enzyme
Novelty:  0.00305479
Score:  0.652
Data Source:  STRINGDB
MERTK
Tchem
Family:  Kinase
Novelty:  0.00382373
Score:  0.645
Data Source:  STRINGDB
PPP1R3B
Tbio
Family:  Enzyme
Novelty:  0.0244434
Score:  0.638
Data Source:  STRINGDB
PPP1R8
Tbio
Family:  Enzyme
Novelty:  0.00138054
Score:  0.626
Data Source:  STRINGDB
CASK
Tchem
Family:  Kinase
Novelty:  0.00856437
Score:  0.583
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
12
7
15
7.5
98.5
triglyceride measurement
8
5
12
2.6
97.5
total cholesterol measurement
8
6
12
2.4
97.1
apolipoprotein B measurement
2
2
2
87.8
blood protein measurement
1
1
1
87.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
15
7.5
98.5
triglyceride measurement
12
2.6
97.5
total cholesterol measurement
12
2.4
97.1
apolipoprotein B measurement
2
87.8
blood protein measurement
1
87.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
T cell immunoglobulin and mucin domain containing 4
VGNC:4198
462217
Macaque
T-cell immunoglobulin and mucin domain containing 4
715236
Mouse
MGI:2445125
276891
Rat
Dog
T cell immunoglobulin and mucin domain containing 4
VGNC:51911
489160
Species
Name
OMA
EggNOG
Inparanoid
Chimp
T cell immunoglobulin and mucin domain containing 4
Macaque
T-cell immunoglobulin and mucin domain containing 4
Mouse
Rat
Dog
T cell immunoglobulin and mucin domain containing 4
Publication Statistics
PubMed Score 155.21
PubMed score by year
PubTator Score 49.85
PubTator score by year
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Related Publications
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PMID
Year
Title