Tbio TIGIT T-cell immunoreceptor with Ig and ITIM domains

Protein Summary

Description

Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.[provided by RefSeq, Sep 2009]

Uniprot Accession IDs

• Q495A1
• Q495A3
• Q5JPD8
• Q6MZS2
• Q8N877

Gene Name

• TIGIT

Ensembl ID

• ENST00000383671
• ENSP00000373167
• ENSG00000181847
• ENST00000486257
• ENSP00000419085

Symbol

• VSIG9
• VSTM3
• VSIG9
• VSTM3
• WUCAM

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.74
protein domain	0.58
microRNA	0.56
tissue	0.49
cell line	0.48

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 318.25   (req: < 5)

Gene RIFs: 118   (req: <= 3)

Antibodies: 275   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 318.25   (req: >= 5)

Gene RIFs: 118   (req: > 3)

Antibodies: 275   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (532 Tissues)

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Circle Plot (2)

Anatomogram

root: immaterial entity (BFO:0000141)

root: material entity (BFO:0000040)

Coexpression Data

Tissue Specific Coexpression (640)

Illuminating Dark Proteins using Reactome Pathways.

Brunson et al., bioRxiv : the preprint server for biology, 2023-06-05

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Coexpressed Target

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EIF3L 28

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IGBP1 22

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EIF3E 22

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PABPC1 17

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PCBP2 16

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EEF1A1 14

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CAMLG 12

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ST13 12

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NPM1 12

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CCNI 11

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EIF3H 11

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SYF2 11

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CCNG1 10

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ZNF277 9

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EIF3D 9

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TOMM20 9

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EIF3F 8

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LTA4H 8

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RSL24D1 8

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RPL5 7

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EIF2S3 7

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NAP1L1 7

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MRPL45 7

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RPL22 6

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RPL15 5

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RPL4 5

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RPL7 5

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BTF3 5

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NSA2 5

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FXR1 5

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NOA1 5

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EEF2 5

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RSL1D1 5

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MKRN1 4

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RPL3 4

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NACA 4

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EIF2A 4

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COPS2 4

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FAM175A 4

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DYM 4

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THG1L 4

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CSNK2A2 4

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NONO 4

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KIAA0430 4

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CSDE1 4

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POLR1D 4

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RPS3A 3

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RPL6 3

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RPL31 3

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COX7A2L 3

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RPL23A 3

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RPS13 3

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LETMD1 3

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DHX40 3

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RPL7A 3

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HNRNPA1 3

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IPO5 3

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POLR1E 3

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ANP32B 3

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EIF4A2 2

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CREBL2 2

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RPS4X 2

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PMPCB 2

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RPS27A 2

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YTHDC1 2

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TFDP2 2

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TMEM192 2

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JAK1 2

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CDK19 2

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RACK1 2

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EEF1G 2

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RPS15A 2

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EIF2D 2

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RPS3 2

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CTSF 2

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RPL14 2

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RPL17 2

Select filter option

RPL11 2

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RPL29 2

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RPL26 2

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RPL23 2

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RPL21 2

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RPL35A 2

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RPL32 2

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RPL30 2

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CCNB1IP1 2

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GLTSCR2 2

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RPS20 2

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RPS27 2

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RPS25 2

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MMGT1 2

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EIF3M 2

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KDELR1 2

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CRTAP 2

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ABCB7 2

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ZFAND1 2

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ELP2 2

Select filter option

RAB4A 1

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RPL36AL 1

Select filter option

PHF3 1

Select filter option

MXI1 1

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QARS 1

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WASF2 1

Select filter option

GGA2 1

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WBP11 1

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NIPAL3 1

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PDXDC1 1

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MAPRE2 1

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CYB5B 1

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MRPS27 1

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MCPH1 1

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PRPS1 1

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ELK4 1

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NFATC2IP 1

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ESYT2 1

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UBE2G2 1

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RBBP7 1

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SET 1

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PRKRA 1

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RFX5 1

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HNRNPH1 1

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TRIM44 1

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AKT3 1

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URI1 1

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DAP3 1

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PHF10 1

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PABPC4 1

Select filter option

QRICH1 1

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KDM2B 1

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PTDSS1 1

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MPRIP 1

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EEF2K 1

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CS 1

Select filter option

TPP2 1

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RBMX 1

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NFX1 1

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DCTD 1

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PJA1 1

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WWP1 1

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DLST 1

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TTC3 1

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TIMM10B 1

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MAP3K4 1

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R3HDM1 1

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TYW1 1

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TULP4 1

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RPL13A 1

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UBXN1 1

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TTF1 1

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MAP2K5 1

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ZNF581 1

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FOXO4 1

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CNBP 1

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RPS6 1

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FBXO7 1

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BFAR 1

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UPF2 1

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CCDC28A 1

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MRPL10 1

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SAV1 1

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RPS11 1

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RPL10A 1

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KIAA1191 1

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TPT1 1

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XRCC5 1

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RPUSD4 1

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PPP1CC 1

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BCL2L13 1

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MMADHC 1

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EIF3A 1

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VDAC2 1

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NMD3 1

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GMPS 1

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OLA1 1

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GDI2 1

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NCOA4 1

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SERBP1 1

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PLAA 1

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CCT4 1

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UBE4B 1

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UQCRC2 1

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MRPL30 1

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KARS 1

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NOB1 1

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PPP6C 1

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METAP2 1

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TXNDC16 1

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SELENOP 1

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ARMCX1 1

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AMFR 1

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G3BP2 1

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NUCKS1 1

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RBSN 1

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SCAPER 1

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CCDC47 1

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PHF20 1

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SERINC1 1

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SLC39A6 1

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ATP9A 1

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RRM1 1

Select filter option

SCARB2 1

Select filter option

FBXW11 1

Select filter option

TMEM159 1

Select filter option

FKBP9 1

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APH1A 1

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MRPL33 1

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SLU7 1

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NBR1 1

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FBXO21 1

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DDX6 1

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RPS8 1

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RPS7 1

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UQCRB 1

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PFDN5 1

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RPL19 1

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TATDN1 1

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RPL24 1

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RPL9 1

Select filter option

RPL8 1

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RPL38 1

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RPL41 1

Select filter option

PHB2 1

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TIMM9 1

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EIF3G 1

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CCDC59 1

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DPH5 1

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RPS23 1

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TOMM7 1

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HSP90AB1 1

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C11orf57 1

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TARSL2 1

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RBMX2 1

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SIRT1 1

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STAG2 1

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EZH1 1

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CRBN 1

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TRIM4 1

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OARD1 1

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OXA1L 1

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CIR1 1

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GID8 1

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KIZ 1

Data Source

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GTEx 640

Tissue

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Thyroid 89

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Ovary 82

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WholeBlood 53

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Artery-Tibial 42

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Pancreas 41

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Esophagus-GastroesophagealJunction 35

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Pituitary 32

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Colon-Sigmoid 31

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Brain-Cerebellum 27

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Esophagus-Muscularis 24

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AdrenalGland 22

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Artery-Aorta 21

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Prostate 19

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Uterus 19

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Kidney-Cortex 15

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Cells-Culturedfibroblasts 14

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Adipose-Subcutaneous 10

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Spleen 8

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Esophagus-Mucosa 6

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MinorSalivaryGland 5

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Artery-Coronary 5

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Nerve-Tibial 5

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Heart-AtrialAppendage 5

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Heart-LeftVentricle 5

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Brain-CerebellarHemisphere 4

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Cells-EBV-transformedlymphocytes 4

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Muscle-Skeletal 3

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Brain-Hippocampus 3

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Lung 2

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Liver 2

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Adipose-Visceral-Omentum 2

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Colon-Transverse 1

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Testis 1

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Brain-Spinalcord-cervicalc-1 1

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Skin-NotSunExposed-Suprapubic 1

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Skin-All 1

Items per page:

5

1 – 5 of 640

Coexpressed Target	Data Source	Tissue	No Header
EIF3L	GTEx	Colon-Transverse
EIF3L	GTEx	Lung
IGBP1	GTEx	Lung
CAMLG	GTEx	MinorSalivaryGland
ST13	GTEx	MinorSalivaryGland

Cancer Specific Coexpression (144)

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Coexpressed Target

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EEF1A1 11

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EIF3L 11

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HNRNPA1 4

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EEF2 4

Select filter option

LETMD1 3

Select filter option

ABCB7 3

Select filter option

RPS3A 2

Select filter option

HBP1 2

Select filter option

ST13 2

Select filter option

IGBP1 2

Select filter option

RSL1D1 2

Select filter option

TOMM20 2

Select filter option

EIF2A 2

Select filter option

ZNF740 2

Select filter option

RPL6 2

Select filter option

NACA 2

Select filter option

NONO 2

Select filter option

LTA4H 2

Select filter option

ABRAXAS1 2

Select filter option

METAP2 2

Select filter option

IPO5 2

Select filter option

EIF3A 2

Select filter option

EEF1B2 2

Select filter option

NPM1 2

Select filter option

RFC1 1

Select filter option

PPP1CC 1

Select filter option

UHRF1BP1L 1

Select filter option

WBP11 1

Select filter option

NUP107 1

Select filter option

PWP1 1

Select filter option

NUP37 1

Select filter option

MAGI3 1

Select filter option

RPL22 1

Select filter option

STAG2 1

Select filter option

KIAA1143 1

Select filter option

TAF1 1

Select filter option

SCAF11 1

Select filter option

POLA1 1

Select filter option

FOPNL 1

Select filter option

FAM122B 1

Select filter option

TWISTNB 1

Select filter option

KDM3A 1

Select filter option

SINHCAF 1

Select filter option

MSI2 1

Select filter option

FAM169A 1

Select filter option

ZNF791 1

Select filter option

ZNF91 1

Select filter option

ITPR2 1

Select filter option

SLC38A1 1

Select filter option

PTGES3 1

Select filter option

MPP5 1

Select filter option

CCNT1 1

Select filter option

PARP8 1

Select filter option

ATF7 1

Select filter option

CTDSP2 1

Select filter option

EIF2S3 1

Select filter option

CCNI 1

Select filter option

LRPPRC 1

Select filter option

MMGT1 1

Select filter option

CSDE1 1

Select filter option

IPO7 1

Select filter option

RPL15 1

Select filter option

BMP2 1

Select filter option

FERMT1 1

Select filter option

FCHSD2 1

Select filter option

PABPC1 1

Select filter option

NAP1L1 1

Select filter option

TCF12 1

Select filter option

RPL3 1

Select filter option

RPL4 1

Select filter option

SIRT1 1

Select filter option

SOX6 1

Select filter option

RPL7 1

Select filter option

EIF3E 1

Select filter option

EIF3H 1

Select filter option

MRPL45 1

Select filter option

RPS23 1

Select filter option

EIF3F 1

Select filter option

NOA1 1

Select filter option

ZNF277 1

Select filter option

CS 1

Select filter option

PABPC4 1

Select filter option

RPL17 1

Select filter option

RPL41 1

Select filter option

RABGGTB 1

Select filter option

RPLP0P6 1

Select filter option

RPLP0 1

Select filter option

SARS 1

Select filter option

PCBP2 1

Select filter option

RPS12 1

Select filter option

RPL10A 1

Select filter option

BTF3 1

Select filter option

EIF4A2 1

Select filter option

RBMX 1

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FAM214A 1

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PFKM 1

Data Source

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TCGA 144

Cancer Type

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KICH 38

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LGG 28

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KIRC 14

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ACC 14

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THCA 8

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MESO 8

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PCPG 7

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UCEC 5

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SARC 4

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CHOL 3

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OV 2

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READ 2

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BLCA 2

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CESC 2

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STAD 1

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THYM 1

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HNSC 1

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PRAD 1

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KIRP 1

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BRCA 1

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LIHC 1

Items per page:

5

1 – 5 of 144

Coexpressed Target	Data Source	Cancer Type	No Header
EEF1A1	TCGA	STAD
RFC1	TCGA	KICH
PPP1CC	TCGA	KICH
HNRNPA1	TCGA	KICH
RPS3A	TCGA	KICH

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (5)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Protein-Protein Interactions (66)

Explore Interacting Targets

1 – 10 of 66

• See Interactions on String-DB

D2HGDH

Tbio

IDG Family:  Enzyme

Novelty:  0.04618268

p_int:  0.999998988

p_ni:  0.000001012

Data Source:  BioPlex

ZDHHC6

Tbio

IDG Family:  Enzyme

Novelty:  0.17384821

p_int:  0.999988842

p_ni:  0.000011158

Data Source:  BioPlex

ZRANB3

Tbio

IDG Family:  Enzyme

Novelty:  0.00398767

p_int:  0.998523984

p_ni:  0.001210499

p_wrong:  0.000265517

Data Source:  BioPlex

UFSP2

Tbio

IDG Family:  Enzyme

Novelty:  0.12630722

p_int:  0.99634528

p_ni:  0.00365472

Data Source:  BioPlex

ITCH

Tbio

IDG Family:  Enzyme

Novelty:  0.00681861

p_int:  0.96455227

p_ni:  0.03544773

Data Source:  BioPlex

CDC6

Tbio

Novelty:  0.00219371

p_int:  0.957965549

p_ni:  0.042026228

p_wrong:  0.000008223

Data Source:  BioPlex

ATP8B2

Tbio

IDG Family:  Transporter

Novelty:  0.09269537

p_int:  0.940682069

p_ni:  0.059317893

p_wrong:  3.8e-8

Data Source:  BioPlex

RHOBTB3

Tbio

Novelty:  0.09149494

p_int:  0.937663396

p_ni:  0.062142479

p_wrong:  0.000194125

Data Source:  BioPlex

FAM171A2

Tdark

Novelty:  1.18763693

p_int:  0.823426445

p_ni:  0.176573538

p_wrong:  1.7e-8

Data Source:  BioPlex

PODXL2

Tbio

Novelty:  0.09100487

p_int:  0.81727413

p_ni:  0.002798605

p_wrong:  0.179927265

Data Source:  BioPlex

Predicted Interactions

Tissue Specific Coexpression (640)

Illuminating Dark Proteins using Reactome Pathways.

Brunson et al., bioRxiv : the preprint server for biology, 2023-06-05

Explore Targets Download Predictions

Coexpressed Target

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EIF3L 28

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IGBP1 22

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EIF3E 22

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PABPC1 17

Select filter option

PCBP2 16

Select filter option

EEF1A1 14

Select filter option

CAMLG 12

Select filter option

ST13 12

Select filter option

NPM1 12

Select filter option

CCNI 11

Select filter option

EIF3H 11

Select filter option

SYF2 11

Select filter option

CCNG1 10

Select filter option

ZNF277 9

Select filter option

EIF3D 9

Select filter option

TOMM20 9

Select filter option

EIF3F 8

Select filter option

LTA4H 8

Select filter option

RSL24D1 8

Select filter option

RPL5 7

Select filter option

EIF2S3 7

Select filter option

NAP1L1 7

Select filter option

MRPL45 7

Select filter option

RPL22 6

Select filter option

RPL15 5

Select filter option

RPL4 5

Select filter option

RPL7 5

Select filter option

BTF3 5

Select filter option

NSA2 5

Select filter option

FXR1 5

Select filter option

NOA1 5

Select filter option

EEF2 5

Select filter option

RSL1D1 5

Select filter option

MKRN1 4

Select filter option

RPL3 4

Select filter option

NACA 4

Select filter option

EIF2A 4

Select filter option

COPS2 4

Select filter option

FAM175A 4

Select filter option

DYM 4

Select filter option

THG1L 4

Select filter option

CSNK2A2 4

Select filter option

NONO 4

Select filter option

KIAA0430 4

Select filter option

CSDE1 4

Select filter option

POLR1D 4

Select filter option

RPS3A 3

Select filter option

RPL6 3

Select filter option

RPL31 3

Select filter option

COX7A2L 3

Select filter option

RPL23A 3

Select filter option

RPS13 3

Select filter option

LETMD1 3

Select filter option

DHX40 3

Select filter option

RPL7A 3

Select filter option

HNRNPA1 3

Select filter option

IPO5 3

Select filter option

POLR1E 3

Select filter option

ANP32B 3

Select filter option

EIF4A2 2

Select filter option

CREBL2 2

Select filter option

RPS4X 2

Select filter option

PMPCB 2

Select filter option

RPS27A 2

Select filter option

YTHDC1 2

Select filter option

TFDP2 2

Select filter option

TMEM192 2

Select filter option

JAK1 2

Select filter option

CDK19 2

Select filter option

RACK1 2

Select filter option

EEF1G 2

Select filter option

RPS15A 2

Select filter option

EIF2D 2

Select filter option

RPS3 2

Select filter option

CTSF 2

Select filter option

RPL14 2

Select filter option

RPL17 2

Select filter option

RPL11 2

Select filter option

RPL29 2

Select filter option

RPL26 2

Select filter option

RPL23 2

Select filter option

RPL21 2

Select filter option

RPL35A 2

Select filter option

RPL32 2

Select filter option

RPL30 2

Select filter option

CCNB1IP1 2

Select filter option

GLTSCR2 2

Select filter option

RPS20 2

Select filter option

RPS27 2

Select filter option

RPS25 2

Select filter option

MMGT1 2

Select filter option

EIF3M 2

Select filter option

KDELR1 2

Select filter option

CRTAP 2

Select filter option

ABCB7 2

Select filter option

ZFAND1 2

Select filter option

ELP2 2

Select filter option

RAB4A 1

Select filter option

RPL36AL 1

Select filter option

PHF3 1

Select filter option

MXI1 1

Select filter option

QARS 1

Select filter option

WASF2 1

Select filter option

GGA2 1

Select filter option

WBP11 1

Select filter option

NIPAL3 1

Select filter option

PDXDC1 1

Select filter option

MAPRE2 1

Select filter option

CYB5B 1

Select filter option

MRPS27 1

Select filter option

MCPH1 1

Select filter option

PRPS1 1

Select filter option

ELK4 1

Select filter option

NFATC2IP 1

Select filter option

ESYT2 1

Select filter option

UBE2G2 1

Select filter option

RBBP7 1

Select filter option

SET 1

Select filter option

PRKRA 1

Select filter option

RFX5 1

Select filter option

HNRNPH1 1

Select filter option

TRIM44 1

Select filter option

AKT3 1

Select filter option

URI1 1

Select filter option

DAP3 1

Select filter option

PHF10 1

Select filter option

PABPC4 1

Select filter option

QRICH1 1

Select filter option

KDM2B 1

Select filter option

PTDSS1 1

Select filter option

MPRIP 1

Select filter option

EEF2K 1

Select filter option

CS 1

Select filter option

TPP2 1

Select filter option

RBMX 1

Select filter option

NFX1 1

Select filter option

DCTD 1

Select filter option

PJA1 1

Select filter option

WWP1 1

Select filter option

DLST 1

Select filter option

TTC3 1

Select filter option

TIMM10B 1

Select filter option

MAP3K4 1

Select filter option

R3HDM1 1

Select filter option

TYW1 1

Select filter option

TULP4 1

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RPL13A 1

Select filter option

UBXN1 1

Select filter option

TTF1 1

Select filter option

MAP2K5 1

Select filter option

ZNF581 1

Select filter option

FOXO4 1

Select filter option

CNBP 1

Select filter option

RPS6 1

Select filter option

FBXO7 1

Select filter option

BFAR 1

Select filter option

UPF2 1

Select filter option

CCDC28A 1

Select filter option

MRPL10 1

Select filter option

SAV1 1

Select filter option

RPS11 1

Select filter option

RPL10A 1

Select filter option

KIAA1191 1

Select filter option

TPT1 1

Select filter option

XRCC5 1

Select filter option

RPUSD4 1

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PPP1CC 1

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BCL2L13 1

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MMADHC 1

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EIF3A 1

Select filter option

VDAC2 1

Select filter option

NMD3 1

Select filter option

GMPS 1

Select filter option

OLA1 1

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GDI2 1

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NCOA4 1

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SERBP1 1

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PLAA 1

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CCT4 1

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UBE4B 1

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UQCRC2 1

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MRPL30 1

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KARS 1

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NOB1 1

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PPP6C 1

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METAP2 1

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TXNDC16 1

Select filter option

SELENOP 1

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ARMCX1 1

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AMFR 1

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G3BP2 1

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NUCKS1 1

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RBSN 1

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SCAPER 1

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CCDC47 1

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PHF20 1

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SERINC1 1

Select filter option

SLC39A6 1

Select filter option

ATP9A 1

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RRM1 1

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SCARB2 1

Select filter option

FBXW11 1

Select filter option

TMEM159 1

Select filter option

FKBP9 1

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APH1A 1

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MRPL33 1

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SLU7 1

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NBR1 1

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FBXO21 1

Select filter option

DDX6 1

Select filter option

RPS8 1

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RPS7 1

Select filter option

UQCRB 1

Select filter option

PFDN5 1

Select filter option

RPL19 1

Select filter option

TATDN1 1

Select filter option

RPL24 1

Select filter option

RPL9 1

Select filter option

RPL8 1

Select filter option

RPL38 1

Select filter option

RPL41 1

Select filter option

PHB2 1

Select filter option

TIMM9 1

Select filter option

EIF3G 1

Select filter option

CCDC59 1

Select filter option

DPH5 1

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RPS23 1

Select filter option

TOMM7 1

Select filter option

HSP90AB1 1

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C11orf57 1

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TARSL2 1

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RBMX2 1

Select filter option

SIRT1 1

Select filter option

STAG2 1

Select filter option

EZH1 1

Select filter option

CRBN 1

Select filter option

TRIM4 1

Select filter option

OARD1 1

Select filter option

OXA1L 1

Select filter option

CIR1 1

Select filter option

GID8 1

Select filter option

KIZ 1

Data Source

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GTEx 640

Tissue

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Thyroid 89

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Ovary 82

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WholeBlood 53

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Artery-Tibial 42

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Pancreas 41

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Esophagus-GastroesophagealJunction 35

Select filter option

Pituitary 32

Select filter option

Colon-Sigmoid 31

Select filter option

Brain-Cerebellum 27

Select filter option

Esophagus-Muscularis 24

Select filter option

AdrenalGland 22

Select filter option

Artery-Aorta 21

Select filter option

Prostate 19

Select filter option

Uterus 19

Select filter option

Kidney-Cortex 15

Select filter option

Cells-Culturedfibroblasts 14

Select filter option

Adipose-Subcutaneous 10

Select filter option

Spleen 8

Select filter option

Esophagus-Mucosa 6

Select filter option

MinorSalivaryGland 5

Select filter option

Artery-Coronary 5

Select filter option

Nerve-Tibial 5

Select filter option

Heart-AtrialAppendage 5

Select filter option

Heart-LeftVentricle 5

Select filter option

Brain-CerebellarHemisphere 4

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Cells-EBV-transformedlymphocytes 4

Select filter option

Muscle-Skeletal 3

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Brain-Hippocampus 3

Select filter option

Lung 2

Select filter option

Liver 2

Select filter option

Adipose-Visceral-Omentum 2

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Colon-Transverse 1

Select filter option

Testis 1

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Brain-Spinalcord-cervicalc-1 1

Select filter option

Skin-NotSunExposed-Suprapubic 1

Select filter option

Skin-All 1

Items per page:

5

1 – 5 of 640

Coexpressed Target	Data Source	Tissue	No Header
EIF3L	GTEx	Colon-Transverse
EIF3L	GTEx	Lung
IGBP1	GTEx	Lung
CAMLG	GTEx	MinorSalivaryGland
ST13	GTEx	MinorSalivaryGland

Cancer Specific Coexpression (144)

Explore Targets Download Predictions

Coexpressed Target

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EEF1A1 11

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EIF3L 11

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HNRNPA1 4

Select filter option

EEF2 4

Select filter option

LETMD1 3

Select filter option

ABCB7 3

Select filter option

RPS3A 2

Select filter option

HBP1 2

Select filter option

ST13 2

Select filter option

IGBP1 2

Select filter option

RSL1D1 2

Select filter option

TOMM20 2

Select filter option

EIF2A 2

Select filter option

ZNF740 2

Select filter option

RPL6 2

Select filter option

NACA 2

Select filter option

NONO 2

Select filter option

LTA4H 2

Select filter option

ABRAXAS1 2

Select filter option

METAP2 2

Select filter option

IPO5 2

Select filter option

EIF3A 2

Select filter option

EEF1B2 2

Select filter option

NPM1 2

Select filter option

RFC1 1

Select filter option

PPP1CC 1

Select filter option

UHRF1BP1L 1

Select filter option

WBP11 1

Select filter option

NUP107 1

Select filter option

PWP1 1

Select filter option

NUP37 1

Select filter option

MAGI3 1

Select filter option

RPL22 1

Select filter option

STAG2 1

Select filter option

KIAA1143 1

Select filter option

TAF1 1

Select filter option

SCAF11 1

Select filter option

POLA1 1

Select filter option

FOPNL 1

Select filter option

FAM122B 1

Select filter option

TWISTNB 1

Select filter option

KDM3A 1

Select filter option

SINHCAF 1

Select filter option

MSI2 1

Select filter option

FAM169A 1

Select filter option

ZNF791 1

Select filter option

ZNF91 1

Select filter option

ITPR2 1

Select filter option

SLC38A1 1

Select filter option

PTGES3 1

Select filter option

MPP5 1

Select filter option

CCNT1 1

Select filter option

PARP8 1

Select filter option

ATF7 1

Select filter option

CTDSP2 1

Select filter option

EIF2S3 1

Select filter option

CCNI 1

Select filter option

LRPPRC 1

Select filter option

MMGT1 1

Select filter option

CSDE1 1

Select filter option

IPO7 1

Select filter option

RPL15 1

Select filter option

BMP2 1

Select filter option

FERMT1 1

Select filter option

FCHSD2 1

Select filter option

PABPC1 1

Select filter option

NAP1L1 1

Select filter option

TCF12 1

Select filter option

RPL3 1

Select filter option

RPL4 1

Select filter option

SIRT1 1

Select filter option

SOX6 1

Select filter option

RPL7 1

Select filter option

EIF3E 1

Select filter option

EIF3H 1

Select filter option

MRPL45 1

Select filter option

RPS23 1

Select filter option

EIF3F 1

Select filter option

NOA1 1

Select filter option

ZNF277 1

Select filter option

CS 1

Select filter option

PABPC4 1

Select filter option

RPL17 1

Select filter option

RPL41 1

Select filter option

RABGGTB 1

Select filter option

RPLP0P6 1

Select filter option

RPLP0 1

Select filter option

SARS 1

Select filter option

PCBP2 1

Select filter option

RPS12 1

Select filter option

RPL10A 1

Select filter option

BTF3 1

Select filter option

EIF4A2 1

Select filter option

RBMX 1

Select filter option

FAM214A 1

Select filter option

PFKM 1

Data Source

Select filter option

TCGA 144

Cancer Type

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KICH 38

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LGG 28

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KIRC 14

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ACC 14

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THCA 8

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MESO 8

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PCPG 7

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UCEC 5

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SARC 4

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CHOL 3

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OV 2

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READ 2

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BLCA 2

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CESC 2

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STAD 1

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THYM 1

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HNSC 1

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PRAD 1

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KIRP 1

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BRCA 1

Select filter option

LIHC 1

Items per page:

5

1 – 5 of 144

Coexpressed Target	Data Source	Cancer Type	No Header
EEF1A1	TCGA	STAD
RFC1	TCGA	KICH
PPP1CC	TCGA	KICH
HNRNPA1	TCGA	KICH
RPS3A	TCGA	KICH

Nearest Tclin Targets

Nearest Tclin calculations are only available for non-Tclin targets that have KEGG Pathway annotations.

Pathways (1)

KEGG (1)

Find Similar Targets

Items per page:

5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Cell adhesion molecules (CAMs)	227 targets	path:hsa04514

Name	Explore in Pharos	Explore in Source
Cell adhesion molecules (CAMs)	227 targets	path:hsa04514

Interacting Pathways

Reactome is a manually curated, peer reviewed knowledgebase of human biological pathways and processes, available online as an open access resource that can be freely used and distributed by all members of the biological research community. This view of the Reactome database displays the pathways functionally interacting with TIGIT.

Viral Interactions (1 Predicted)

Find Similar Targets

1 – 1 of 1

Human adenovirus 18

(1 predicted interaction)

Virus Details

Virus type:  dsDNA

Taxonomy ID:  10528

Family:  Adenoviridae

Genus:  Mastadenovirus

Species:  Human mastadenovirus A

Interacting Viral Proteins (1)

CR1-beta protein (gene: E3)

NCBI:  ACZ92166.1

finalLR:  910.27

Gene Ontology Terms (8)

Functions (2)

Components (3)

Processes (3)

Find Similar Targets

Items per page:

5

1 – 2 of 2

GO Term	Evidence	Assigned by
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
signaling receptor binding	Inferred from Physical Interaction (IPI)	MGI

Disease Associations (6)

Explore Associated Diseases Find Similar Targets

1 – 6 of 6

cancer

JensenLab Text Mining

Explore Disease: cancer

JensenLab Text Mining

• Disease ID:  DOID:162
• zscore:  6.085
• Confidence:  3

osteosarcoma

Expression Atlas

Explore Disease: osteosarcoma

Expression Atlas

• Disease ID:  DOID:3347
• Log 2 fold change:  -1.265
• p-value:  0.00137464570359073

interstitial cystitis

Expression Atlas

Explore Disease: interstitial cystitis

Expression Atlas

• Disease ID:  DOID:13949
• Log 2 fold change:  2
• p-value:  0.00157223468960736

psoriasis

Expression Atlas

Explore Disease: psoriasis

Expression Atlas

• Disease ID:  DOID:8893
• Log 2 fold change:  2.2
• p-value:  2.27537459101534e-92

invasive ductal breast carcinoma

Expression Atlas

Explore Disease: invasive ductal breast carcinoma

Expression Atlas

• Disease ID:  DOID:3008
• Log 2 fold change:  1.1
• p-value:  0.0246011311672486

Sjogren syndrome

Expression Atlas

Explore Disease: Sjogren syndrome

Expression Atlas

• Disease ID:  DOID:12894
• Log 2 fold change:  1.4
• p-value:  0.0015980918903021

Predicted Diseases

Tissue Specific Coexpression (640)

Illuminating Dark Proteins using Reactome Pathways.

Brunson et al., bioRxiv : the preprint server for biology, 2023-06-05

Explore Targets Download Predictions

Coexpressed Target

Select filter option

EIF3L 28

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IGBP1 22

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EIF3E 22

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PABPC1 17

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PCBP2 16

Select filter option

EEF1A1 14

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CAMLG 12

Select filter option

ST13 12

Select filter option

NPM1 12

Select filter option

CCNI 11

Select filter option

EIF3H 11

Select filter option

SYF2 11

Select filter option

CCNG1 10

Select filter option

ZNF277 9

Select filter option

EIF3D 9

Select filter option

TOMM20 9

Select filter option

EIF3F 8

Select filter option

LTA4H 8

Select filter option

RSL24D1 8

Select filter option

RPL5 7

Select filter option

EIF2S3 7

Select filter option

NAP1L1 7

Select filter option

MRPL45 7

Select filter option

RPL22 6

Select filter option

RPL15 5

Select filter option

RPL4 5

Select filter option

RPL7 5

Select filter option

BTF3 5

Select filter option

NSA2 5

Select filter option

FXR1 5

Select filter option

NOA1 5

Select filter option

EEF2 5

Select filter option

RSL1D1 5

Select filter option

MKRN1 4

Select filter option

RPL3 4

Select filter option

NACA 4

Select filter option

EIF2A 4

Select filter option

COPS2 4

Select filter option

FAM175A 4

Select filter option

DYM 4

Select filter option

THG1L 4

Select filter option

CSNK2A2 4

Select filter option

NONO 4

Select filter option

KIAA0430 4

Select filter option

CSDE1 4

Select filter option

POLR1D 4

Select filter option

RPS3A 3

Select filter option

RPL6 3

Select filter option

RPL31 3

Select filter option

COX7A2L 3

Select filter option

RPL23A 3

Select filter option

RPS13 3

Select filter option

LETMD1 3

Select filter option

DHX40 3

Select filter option

RPL7A 3

Select filter option

HNRNPA1 3

Select filter option

IPO5 3

Select filter option

POLR1E 3

Select filter option

ANP32B 3

Select filter option

EIF4A2 2

Select filter option

CREBL2 2

Select filter option

RPS4X 2

Select filter option

PMPCB 2

Select filter option

RPS27A 2

Select filter option

YTHDC1 2

Select filter option

TFDP2 2

Select filter option

TMEM192 2

Select filter option

JAK1 2

Select filter option

CDK19 2

Select filter option

RACK1 2

Select filter option

EEF1G 2

Select filter option

RPS15A 2

Select filter option

EIF2D 2

Select filter option

RPS3 2

Select filter option

CTSF 2

Select filter option

RPL14 2

Select filter option

RPL17 2

Select filter option

RPL11 2

Select filter option

RPL29 2

Select filter option

RPL26 2

Select filter option

RPL23 2

Select filter option

RPL21 2

Select filter option

RPL35A 2

Select filter option

RPL32 2

Select filter option

RPL30 2

Select filter option

CCNB1IP1 2

Select filter option

GLTSCR2 2

Select filter option

RPS20 2

Select filter option

RPS27 2

Select filter option

RPS25 2

Select filter option

MMGT1 2

Select filter option

EIF3M 2

Select filter option

KDELR1 2

Select filter option

CRTAP 2

Select filter option

ABCB7 2

Select filter option

ZFAND1 2

Select filter option

ELP2 2

Select filter option

RAB4A 1

Select filter option

RPL36AL 1

Select filter option

PHF3 1

Select filter option

MXI1 1

Select filter option

QARS 1

Select filter option

WASF2 1

Select filter option

GGA2 1

Select filter option

WBP11 1

Select filter option

NIPAL3 1

Select filter option

PDXDC1 1

Select filter option

MAPRE2 1

Select filter option

CYB5B 1

Select filter option

MRPS27 1

Select filter option

MCPH1 1

Select filter option

PRPS1 1

Select filter option

ELK4 1

Select filter option

NFATC2IP 1

Select filter option

ESYT2 1

Select filter option

UBE2G2 1

Select filter option

RBBP7 1

Select filter option

SET 1

Select filter option

PRKRA 1

Select filter option

RFX5 1

Select filter option

HNRNPH1 1

Select filter option

TRIM44 1

Select filter option

AKT3 1

Select filter option

URI1 1

Select filter option

DAP3 1

Select filter option

PHF10 1

Select filter option

PABPC4 1

Select filter option

QRICH1 1

Select filter option

KDM2B 1

Select filter option

PTDSS1 1

Select filter option

MPRIP 1

Select filter option

EEF2K 1

Select filter option

CS 1

Select filter option

TPP2 1

Select filter option

RBMX 1

Select filter option

NFX1 1

Select filter option

DCTD 1

Select filter option

PJA1 1

Select filter option

WWP1 1

Select filter option

DLST 1

Select filter option

TTC3 1

Select filter option

TIMM10B 1

Select filter option

MAP3K4 1

Select filter option

R3HDM1 1

Select filter option

TYW1 1

Select filter option

TULP4 1

Select filter option

RPL13A 1

Select filter option

UBXN1 1

Select filter option

TTF1 1

Select filter option

MAP2K5 1

Select filter option

ZNF581 1

Select filter option

FOXO4 1

Select filter option

CNBP 1

Select filter option

RPS6 1

Select filter option

FBXO7 1

Select filter option

BFAR 1

Select filter option

UPF2 1

Select filter option

CCDC28A 1

Select filter option

MRPL10 1

Select filter option

SAV1 1

Select filter option

RPS11 1

Select filter option

RPL10A 1

Select filter option

KIAA1191 1

Select filter option

TPT1 1

Select filter option

XRCC5 1

Select filter option

RPUSD4 1

Select filter option

PPP1CC 1

Select filter option

BCL2L13 1

Select filter option

MMADHC 1

Select filter option

EIF3A 1

Select filter option

VDAC2 1

Select filter option

NMD3 1

Select filter option

GMPS 1

Select filter option

OLA1 1

Select filter option

GDI2 1

Select filter option

NCOA4 1

Select filter option

SERBP1 1

Select filter option

PLAA 1

Select filter option

CCT4 1

Select filter option

UBE4B 1

Select filter option

UQCRC2 1

Select filter option

MRPL30 1

Select filter option

KARS 1

Select filter option

NOB1 1

Select filter option

PPP6C 1

Select filter option

METAP2 1

Select filter option

TXNDC16 1

Select filter option

SELENOP 1

Select filter option

ARMCX1 1

Select filter option

AMFR 1

Select filter option

G3BP2 1

Select filter option

NUCKS1 1

Select filter option

RBSN 1

Select filter option

SCAPER 1

Select filter option

CCDC47 1

Select filter option

PHF20 1

Select filter option

SERINC1 1

Select filter option

SLC39A6 1

Select filter option

ATP9A 1

Select filter option

RRM1 1

Select filter option

SCARB2 1

Select filter option

FBXW11 1

Select filter option

TMEM159 1

Select filter option

FKBP9 1

Select filter option

APH1A 1

Select filter option

MRPL33 1

Select filter option

SLU7 1

Select filter option

NBR1 1

Select filter option

FBXO21 1

Select filter option

DDX6 1

Select filter option

RPS8 1

Select filter option

RPS7 1

Select filter option

UQCRB 1

Select filter option

PFDN5 1

Select filter option

RPL19 1

Select filter option

TATDN1 1

Select filter option

RPL24 1

Select filter option

RPL9 1

Select filter option

RPL8 1

Select filter option

RPL38 1

Select filter option

RPL41 1

Select filter option

PHB2 1

Select filter option

TIMM9 1

Select filter option

EIF3G 1

Select filter option

CCDC59 1

Select filter option

DPH5 1

Select filter option

RPS23 1

Select filter option

TOMM7 1

Select filter option

HSP90AB1 1

Select filter option

C11orf57 1

Select filter option

TARSL2 1

Select filter option

RBMX2 1

Select filter option

SIRT1 1

Select filter option

STAG2 1

Select filter option

EZH1 1

Select filter option

CRBN 1

Select filter option

TRIM4 1

Select filter option

OARD1 1

Select filter option

OXA1L 1

Select filter option

CIR1 1

Select filter option

GID8 1

Select filter option

KIZ 1

Data Source

Select filter option

GTEx 640

Tissue

Select filter option

Thyroid 89

Select filter option

Ovary 82

Select filter option

WholeBlood 53

Select filter option

Artery-Tibial 42

Select filter option

Pancreas 41

Select filter option

Esophagus-GastroesophagealJunction 35

Select filter option

Pituitary 32

Select filter option

Colon-Sigmoid 31

Select filter option

Brain-Cerebellum 27

Select filter option

Esophagus-Muscularis 24

Select filter option

AdrenalGland 22

Select filter option

Artery-Aorta 21

Select filter option

Prostate 19

Select filter option

Uterus 19

Select filter option

Kidney-Cortex 15

Select filter option

Cells-Culturedfibroblasts 14

Select filter option

Adipose-Subcutaneous 10

Select filter option

Spleen 8

Select filter option

Esophagus-Mucosa 6

Select filter option

MinorSalivaryGland 5

Select filter option

Artery-Coronary 5

Select filter option

Nerve-Tibial 5

Select filter option

Heart-AtrialAppendage 5

Select filter option

Heart-LeftVentricle 5

Select filter option

Brain-CerebellarHemisphere 4

Select filter option

Cells-EBV-transformedlymphocytes 4

Select filter option

Muscle-Skeletal 3

Select filter option

Brain-Hippocampus 3

Select filter option

Lung 2

Select filter option

Liver 2

Select filter option

Adipose-Visceral-Omentum 2

Select filter option

Colon-Transverse 1

Select filter option

Testis 1

Select filter option

Brain-Spinalcord-cervicalc-1 1

Select filter option

Skin-NotSunExposed-Suprapubic 1

Select filter option

Skin-All 1

Items per page:

5

1 – 5 of 640

Coexpressed Target	Data Source	Tissue	No Header
EIF3L	GTEx	Colon-Transverse
EIF3L	GTEx	Lung
IGBP1	GTEx	Lung
CAMLG	GTEx	MinorSalivaryGland
ST13	GTEx	MinorSalivaryGland

Cancer Specific Coexpression (144)

Explore Targets Download Predictions

Coexpressed Target

Select filter option

EEF1A1 11

Select filter option

EIF3L 11

Select filter option

HNRNPA1 4

Select filter option

EEF2 4

Select filter option

LETMD1 3

Select filter option

ABCB7 3

Select filter option

RPS3A 2

Select filter option

HBP1 2

Select filter option

ST13 2

Select filter option

IGBP1 2

Select filter option

RSL1D1 2

Select filter option

TOMM20 2

Select filter option

EIF2A 2

Select filter option

ZNF740 2

Select filter option

RPL6 2

Select filter option

NACA 2

Select filter option

NONO 2

Select filter option

LTA4H 2

Select filter option

ABRAXAS1 2

Select filter option

METAP2 2

Select filter option

IPO5 2

Select filter option

EIF3A 2

Select filter option

EEF1B2 2

Select filter option

NPM1 2

Select filter option

RFC1 1

Select filter option

PPP1CC 1

Select filter option

UHRF1BP1L 1

Select filter option

WBP11 1

Select filter option

NUP107 1

Select filter option

PWP1 1

Select filter option

NUP37 1

Select filter option

MAGI3 1

Select filter option

RPL22 1

Select filter option

STAG2 1

Select filter option

KIAA1143 1

Select filter option

TAF1 1

Select filter option

SCAF11 1

Select filter option

POLA1 1

Select filter option

FOPNL 1

Select filter option

FAM122B 1

Select filter option

TWISTNB 1

Select filter option

KDM3A 1

Select filter option

SINHCAF 1

Select filter option

MSI2 1

Select filter option

FAM169A 1

Select filter option

ZNF791 1

Select filter option

ZNF91 1

Select filter option

ITPR2 1

Select filter option

SLC38A1 1

Select filter option

PTGES3 1

Select filter option

MPP5 1

Select filter option

CCNT1 1

Select filter option

PARP8 1

Select filter option

ATF7 1

Select filter option

CTDSP2 1

Select filter option

EIF2S3 1

Select filter option

CCNI 1

Select filter option

LRPPRC 1

Select filter option

MMGT1 1

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CSDE1 1

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TCGA 144

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KICH 38

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LGG 28

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KIRC 14

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ACC 14

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THCA 8

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Coexpressed Target	Data Source	Cancer Type	No Header
EEF1A1	TCGA	STAD
RFC1	TCGA	KICH
PPP1CC	TCGA	KICH
HNRNPA1	TCGA	KICH
RPS3A	TCGA	KICH

Disease Novelty (TIN-X)

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root: disease (DOID:4)

GWAS Traits (6)

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
balding measurement	EFO_0007825	1	2	2		81
smoking status measurement	EFO_0006527	2	1	2		64.9
post-traumatic stress disorder	EFO_0001358	1	1	1		37.6
risk-taking behaviour	EFO_0008579	1	1	1		30.2
feeling emotionally hurt measurement	EFO_0009599	1	1	0	5.5	23.7

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
balding measurement	EFO_0007825	2		81
smoking status measurement	EFO_0006527	2		64.9
post-traumatic stress disorder	EFO_0001358	1		37.6
risk-taking behaviour	EFO_0008579	1		30.2
feeling emotionally hurt measurement	EFO_0009599	0	5.5	23.7

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3D-structure
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GWAS Trait Find Similar Targets

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balding measurement
feeling emotionally hurt measurement
post-traumatic stress disorder
risk-taking behaviour
smoking initiation
smoking status measurement

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cellular phenotype
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Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	T cell immunoreceptor with Ig and ITIM domains	VGNC:2604	470887
Mouse	T cell immunoreceptor with Ig and ITIM domains	MGI:3642260	100043314
Rat	T cell immunoreceptor with Ig and ITIM domains	RGD:1563191	363784
Dog	T cell immunoreceptor with Ig and ITIM domains	VGNC:47374	487986
Horse	T cell immunoreceptor with Ig and ITIM domains	VGNC:24107	100071301

Species	Name	OMA	EggNOG	Inparanoid
Chimp	T cell immunoreceptor with Ig and ITIM domains
Mouse	T cell immunoreceptor with Ig and ITIM domains
Rat	T cell immunoreceptor with Ig and ITIM domains
Dog	T cell immunoreceptor with Ig and ITIM domains
Horse	T cell immunoreceptor with Ig and ITIM domains

Publication Statistics

PubMed Score 318.25

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PubTator Score 40.68

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Publications (123)

Overrepresented Terms from Abstracts

0 terms from up to 100 abstracts, scaled based on the degree of overrepresentation (Fisher's Exact Test p-Value).

PublicationsGeneRIFs

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1 – 5 of 123

The immune checkpoint TIGIT/CD155 promotes the exhaustion of CD8 + T cells in TNBC through glucose metabolic reprogramming mediated by PI3K/AKT/mTOR signaling.

Huang et al., Cell communication and signaling : CCS, 2024-01-12

GeneRIF:

The immune checkpoint TIGIT/CD155 promotes the exhaustion of CD8 + T cells in TNBC through glucose metabolic reprogramming mediated by PI3K/AKT/mTOR signaling.

Abstract: (show)

The CD155/TIGIT axis has attracted considerable interest as an emerging immune checkpoint with potential applications in cancer immunotherapy. Our research focused on investigating the role of CD155/TIGIT checkpoints in the progression of triple-negative breast cancer (TNBC).

Decreased expression of TIGIT on CD14 + monocytes correlates with clinical features and laboratory parameters of patients with primary Sjögren's syndrome.

Zhao et al., Clinical rheumatology, 2024-01

GeneRIF:

Decreased expression of TIGIT on CD14 + monocytes correlates with clinical features and laboratory parameters of patients with primary Sjogren's syndrome.

Abstract: (show)

The purpose of this study was to investigate the expression of T-cell immunoglobulin and ITIM domain (TIGIT) in peripheral circulation of primary Sjögren's syndrome (pSS) and its role in the development of pSS.

[Expression and effect of TIGIT in peripheral blood CD56+ T cells of patients with rheumatoid arthritis].

Zhu et al., Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2023-11-20

Abstract: (show)

Objective To investigate the proportional change of CD56+ T cells in peripheral blood of patients with rheumatoid arthritis (RA) and the expression of T cell immunoglobulin and immune receptor tyrosine inhibitory motif domain (TIGIT) on the surface of CD56+ T cells, and to explore the effect of TIGIT on CD56+ T cell function in RA. Methods Fifty patients with RA and twenty healthy controls were selected. Flow cytometry was used to determine the proportion of CD56+ T cells in peripheral blood, and the correlation between the resulting cell ratio and clinical indicators of the disease was analyzed. Flow cytometry was used to measure the expression level of TIGIT in peripheral blood CD56+ T cells in RA patients. Density gradient centrifugation was used to isolate peripheral blood mononuclear cells which were subsequently cultured in vitro. The proportion of CD56+ T cells expressing Interferon-γ (IFN-γ) and Interleukin-17A (IL-17A) in peripheral blood of RA patients were measured. The differential expression of IFN-γ and IL-17A in TIGIT- CD56+ T cells and TIGIT+ CD56+ T cells was investigated. The serum IL-17A levels in RA patients were assayed by ELISA. Results Compared with the healthy controls, the proportion of CD56+ T cells in peripheral blood was reduced in RA patients, and the proportion of CD56+ T cells expressing IL-17A was significantly reduced; Serum IL-17A concentration was elevated in RA patients. CD56+ T cells in RA patients were with higher expression of TIGIT molecules, and IFN-γ was mainly derived from TIGIT- CD56+ T cells. There was no significant difference between the proportion of TIGIT- CD56+ T cells and TIGIT+ CD56+ T cells expressing IL-17A. Conclusion Abnormal expression of TIGIT affects cytokine secretion function of CD56+ T cells, which in turn participates in the RA disease progression. And IFN-γ is mainly derived from TIGIT- CD56+ T cells. However, TIGIT may not affect the IL-17A secretion level of CD56+ T cells.

IL-21 collaborates with anti-TIGIT to restore NK cell function in chronic HBV infection.

Tang et al., Journal of medical virology, 2023-10

Abstract: (show)

Available therapies for chronic hepatitis B virus (HBV) infection are not satisfying, and interleukin-21 (IL-21) and checkpoint inhibitors are potential therapeutic options. However, the mechanism underlying IL-21 and checkpoint inhibitors in treating chronic HBV infection is unclear. To explore whether IL-21 and checkpoint inhibitors promote HBV clearance by modulating the function of natural killer (NK) cells, we measured the phenotypes and functions of NK cells in chronic HBV-infected patients and healthy controls on mRNA and protein levels. We found that chronic HBV infection disturbed the transcriptome of NK cells, including decreased expression of KLRK1, TIGIT, GZMA, PRF1, and increased expression of CD69. We also observed altered phenotypes and functions of NK cells in chronic HBV-infected patients, characterized by decreased NKG2D expression, increased TIGIT expression and impaired interferon-gamma (IFN-γ), tumor necrosis factor-alpha (TNF-α) production. Furthermore, these alterations cannot be restored by telbivudine treatment but can be partially restored by IL-21 and anti-TIGIT stimulation. IL-21 upregulated the expression of activating receptor CD16, CD69, and NKG2D on NK cells, enhanced IFN-γ production, cytolysis, and proliferation of NK cells, while anti-TIGIT promoted IFN-γ production in CD56dim subset exclusively in chronic HBV infected patients. Additionally, IL-21 was indispensable for anti-TIGIT in HBsAg clearance in mice bearing HBV. It enhanced IFN-γ production in splenic NK cells rather than intrahepatic NK cells, indicating a brand-new mechanism of IL-21 in HBV clearance when combined with anti-TIGIT. Overall, our findings contribute to the design of immunotherapy through enhancing the antiviral efficacy of NK cells in chronic HBV infection.

CD155 and Its Receptors as Targets for Cancer Therapy.

Rossella Paolini, Rosa Molfetta, International journal of molecular sciences, 2023-08-19

Abstract: (show)

CD155, also known as the poliovirus receptor, is an adhesion molecule often overexpressed in tumors of different origins where it promotes cell migration and proliferation. In addition to this pro-tumorigenic function, CD155 plays an immunomodulatory role during tumor progression since it is a ligand for both the activating receptor DNAM-1 and the inhibitory receptor TIGIT, expressed on cytotoxic innate and adaptative lymphocytes. DNAM-1 is a well-recognized receptor involved in anti-tumor immune surveillance. However, in advanced tumor stages, TIGIT is up-regulated and acts as an immune checkpoint receptor, counterbalancing DNAM-1-mediated cancer cell clearance. Pre-clinical studies have proposed the direct targeting of CD155 on tumor cells as well as the enhancement of DNAM-1-mediated anti-tumor functions as promising therapeutic approaches. Moreover, immunotherapeutic use of anti-TIGIT blocking antibody alone or in combined therapy has already been included in clinical trials. The aim of this review is to summarize all these potential therapies, highlighting the still controversial role of CD155 during tumor progression.