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Tbio
TIGIT
T-cell immunoreceptor with Ig and ITIM domains

Protein Summary
Description
Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.[provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000383671
  • ENSP00000373167
  • ENSG00000181847
  • ENST00000486257
  • ENSP00000419085

Symbol
  • VSIG9
  • VSTM3
  • VSIG9
  • VSTM3
  • WUCAM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.74
protein domain
0.58
microRNA
0.56
tissue
0.49
cell line
0.48


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 218.25   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 275   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 218.25   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 275   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (66)
D2HGDH
Tbio
Family:  Enzyme
Novelty:  0.04618268
p_int:  0.999998988
p_ni:  0.000001012
Data Source:  BioPlex
ZDHHC6
Tbio
Family:  Enzyme
Novelty:  0.17384821
p_int:  0.999988842
p_ni:  0.000011158
Data Source:  BioPlex
ZRANB3
Tbio
Family:  Enzyme
Novelty:  0.00398767
p_int:  0.998523984
p_ni:  0.001210499
p_wrong:  0.000265517
Data Source:  BioPlex
UFSP2
Tbio
Family:  Enzyme
Novelty:  0.12630722
p_int:  0.99634528
p_ni:  0.00365472
Data Source:  BioPlex
ITCH
Tbio
Family:  Enzyme
Novelty:  0.00681861
p_int:  0.96455227
p_ni:  0.03544773
Data Source:  BioPlex
CDC6
Tbio
Novelty:  0.00219371
p_int:  0.957965549
p_ni:  0.042026228
p_wrong:  0.000008223
Data Source:  BioPlex
ATP8B2
Tbio
Family:  Transporter
Novelty:  0.09269537
p_int:  0.940682069
p_ni:  0.059317893
p_wrong:  3.8e-8
Data Source:  BioPlex
RHOBTB3
Tbio
Novelty:  0.09149494
p_int:  0.937663396
p_ni:  0.062142479
p_wrong:  0.000194125
Data Source:  BioPlex
FAM171A2
Tdark
Novelty:  1.18763693
p_int:  0.823426445
p_ni:  0.176573538
p_wrong:  1.7e-8
Data Source:  BioPlex
PODXL2
Tbio
Novelty:  0.09100487
p_int:  0.81727413
p_ni:  0.002798605
p_wrong:  0.179927265
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
2
2
79.2
smoking status measurement
2
1
2
61.4
risk-taking behaviour
1
1
1
24.5
feeling emotionally hurt measurement
1
1
0
5.5
17.8
smoking initiation
1
1
1
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
2
79.2
smoking status measurement
2
61.4
risk-taking behaviour
1
24.5
feeling emotionally hurt measurement
0
5.5
17.8
smoking initiation
1
14.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
T cell immunoreceptor with Ig and ITIM domains
VGNC:2604
470887
Mouse
MGI:3642260
100043314
Rat
RGD:1563191
363784
Dog
T cell immunoreceptor with Ig and ITIM domains
VGNC:47374
487986
Horse
T cell immunoreceptor with Ig and ITIM domains
VGNC:24107
100071301
Species
Name
OMA
EggNOG
Inparanoid
Chimp
T cell immunoreceptor with Ig and ITIM domains
Mouse
Rat
Dog
T cell immunoreceptor with Ig and ITIM domains
Horse
T cell immunoreceptor with Ig and ITIM domains
Publication Statistics
PubMed Score 218.25
PubMed score by year
PubTator Score 40.68
PubTator score by year
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Related Publications
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PMID
Year
Title